[en] Four new acylated triterpene glycosides (1-4) have been isolated as two inseparable mixtures of the trans- and cis-3,4,5-trimethoxycinnamoyl derivatives (1,2 and 3,4) from the roots of Muraltia heisteria. The structures of these compounds were elucidated by various 1D and 2D NMR techniques, including H-1 and C-13, COSY, NOESY, HSQC, TOCSY, and HMBC experiments and FABMS. Compounds 3 and 4 were shown to be cytotoxic in a human colon cancer cell line but did not show any ability to potentiate in vitro cisplatin cytotoxicity.
Disciplines :
Chemistry Phytobiology (plant sciences, forestry, mycology...) Chemical engineering
Author, co-author :
Elbandy, M.
Miyamoto, T.
Chauffert, B.
Delaude, Clément ; Université de Liège - ULiège > Relations académiques et scientifiques (Sciences)
Lacaille-Dubois, M. A.
Language :
English
Title :
Novel acylated triterpene glycosides from Muraltia heisteria
Publication date :
February 2002
Journal title :
Journal of Natural Products
ISSN :
0163-3864
eISSN :
1520-6025
Publisher :
American Chemical Society, United States - District of Columbia
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