Article (Scientific journals)
Immune checkpoint inhibitors for progressive multifocal leukoencephalopathy: identifying relevant outcome factors
Lambert, Nicolas; El Moussaoui, Majdouline; MAQUET, Pierre
2021In European Journal of Neurology
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Keywords :
immune checkpoint inhibitor; nivolumab; pembrolizumab; progressive multifocal leukoencephalopathy
Abstract :
[en] Introduction: Progressive multifocal leukoencephalopathy (PML) is an infectious brain disease caused by JC virus in immunocompromised individuals. Immune checkpoint inhibitors (ICIs) recently emerged as a therapeutic hope for these patients but identification of those likely to respond to the treatment is still an unmet need. Method: We performed a systematic PubMed search for reports of patients treated for PML using an ICI. Clinical, biological and radiological characteristics were contrasted between patients who responded to the treatment (RP) and those who did not (NRP). Results: 35 patients were included in the present study. 21 of them reportedly benefited from the treatment. Age, blood CD4+ cells count, pre-treatment viral load in the cerebrospinal fluid (CSF), PML lesions localization, treatment delay since first PML symptoms, type of ICI used and immune-related adverse events (irAEs) occurrence did not significantly differ between RP and NRP. By contrast, a history of therapeutic immune suppression and the use of an immunosuppressive therapy at treatment initiation were significantly associated with a poor response. Besides, reaching an undetectable viral load the CSF and reduction of the lesion load on magnetic resonance imaging after ICI administration were associated with a good clinical response. Conclusion: Current data suggest that patients with PML under immunosuppressive therapy are less likely to respond to ICIs and raise the issue of the optimal management of irAEs during ICI treatment in this setting.
Disciplines :
Neurology
Immunology & infectious disease
Author, co-author :
Lambert, Nicolas  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
El Moussaoui, Majdouline  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'hématologie clinique
MAQUET, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Language :
English
Title :
Immune checkpoint inhibitors for progressive multifocal leukoencephalopathy: identifying relevant outcome factors
Publication date :
12 July 2021
Journal title :
European Journal of Neurology
ISSN :
1351-5101
eISSN :
1468-1331
Publisher :
Blackwell, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 July 2021

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