Article (Scientific journals)
Bioinformatics tools for the discovery of new lipopeptides with biocontrol applications
Pupin, M.; Flissi, A.; Jacques, Philippe et al.
2018In European Journal of Plant Pathology, 152 (4), p. 993-1001
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Keywords :
Biocontrol; Bioinformatics; Lipopeptide; Norine; NRPS; Fungi; Pseudomonas; Rhizobiales
Abstract :
[en] As conventional or chemical pesticides have negative impact on environment and health of both farmer and consumers, it becomes relevant to develop alternative solutions to limit their use. In this context, innovative strategies to accelerate the development of biocontrol agents are welcome. For a decade of years, it has been demonstrated that lipopeptides are very efficient weapons against fungi responsible for crop diseases. Lipopeptides are secondary metabolites, produced by many microorganisms including beneficial rhizobacteria. The lipopeptide biosynthetic pathways include nonribosomal peptide synthetases. These modular enzymatic complexes work as assembly lines to build the peptides step by step, leading to the production of original peptide compounds with specific features as the presence of non proteinogenic monomers and cyclic and branched structures. In this paper, Florine and Norine bioinformatics tools, especially dedicated to non-ribosomal synthetases and their products are presented. Their use is mainly focused on the discovery of lipopeptides produced by Bacillus or Pseudomonas because they seem to represent a versatile reservoir of active secondary metabolites with promising activities for applications in phytosanitary area. © 2018, Koninklijke Nederlandse Planteziektenkundige Vereniging.
Disciplines :
Biotechnology
Author, co-author :
Pupin, M.;  Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France, Inria-Lille Nord Europe, Bonsai Team, Villeneuve d’Ascq Cedex, F-59655, France
Flissi, A.;  Univ. Lille, CNRS, Centrale Lille, UMR 9189 - CRIStAL - Centre de Recherche en Informatique Signal et Automatique de Lille, Lille, F-59000, France, Inria-Lille Nord Europe, Bonsai Team, Villeneuve d’Ascq Cedex, F-59655, France
Jacques, Philippe ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
Leclère, V.;  Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d’Opale, EA 7394-ICV- Institut Charles Viollette, Lille, F-59000, France
Language :
English
Title :
Bioinformatics tools for the discovery of new lipopeptides with biocontrol applications
Publication date :
2018
Journal title :
European Journal of Plant Pathology
ISSN :
0929-1873
eISSN :
1573-8469
Publisher :
Springer Netherlands
Volume :
152
Issue :
4
Pages :
993-1001
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
InterregEuropean Commission, EC
Available on ORBi :
since 06 July 2021

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