Article (Scientific journals)
Loss-in-weight feeding, powder flow and electrostatic evaluation for direct compression hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing
Allenspach, C.; Timmins, P.; Lumay, Geoffroy et al.
2021In International Journal of Pharmaceutics, 596
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Keywords :
Electrostatics; Excipient; Hypromellose; Pharmaceutical; Powder flow; Screw feeder; Triboelectric charging; Article; Hausner ratio; Chemistry, Pharmaceutical; Delayed-Action Preparations; Hypromellose Derivatives; Methylcellulose; Powders; Static Electricity
Abstract :
[en] Minimizing variability in the feeding process is important for continuous manufacturing since materials are fed individually and can impact the final product. This study demonstrates the importance of measuring powder properties and highlights the need to characterize the feeding performance both offline with multiple refills and in the intended configuration for the continuous manufacturing equipment. The standard grade hydroxypropyl methylcellulose (HPMC) had material buildup on the loss-in-weight feeder barrel from triboelectric charging and resulted in more mass flow excursions and failed refills which were not observed with the direct compression grades. The location of the electrostatic buildup changed when the feeder was connected to a hopper instead of feeding offline into a collection bucket. Overall, the direct compression HPMC exhibited better flow which resulted in more accurate loss-in-weight feeding with less excursions from the target mass flow and all refills were completed in the first attempt. The improvements with the direct compression HPMC would be beneficial when running any continuous process (wet granulation, roller compaction, or direct compression) or other processes where loss-in-weight feeding is utilized, such as melt extrusion or twin screw granulation. © 2021 Elsevier B.V.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Allenspach, C.;  Bristol-Myers Squibb, 1 Squibb Dr., New Brunswick, NJ 08901, United States
Timmins, P.;  Bristol-Myers Squibb, Reeds Lane, Moreton Merseyside, CH46 1QW, United Kingdom
Lumay, Geoffroy ;  Université de Liège - ULiège > Département de physique > Physique expér. de la matière molle et des syst. complexes
Holman, J.;  GEA Group, Technology Management Pharma Solids, Wommelgem, Belgium
Minko, T.;  Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, United States
Language :
English
Title :
Loss-in-weight feeding, powder flow and electrostatic evaluation for direct compression hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing
Publication date :
2021
Journal title :
International Journal of Pharmaceutics
ISSN :
0378-5173
eISSN :
1873-3476
Publisher :
Elsevier B.V.
Volume :
596
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 July 2021

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