[en] P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results showed a significant reduction of P200, P300, and CNV and a significant increase of postimperative negative variation (PINV) in patients who had attempted suicide compared to patients with a negative history. Moreover, P300 amplitude was negatively related with the Suicidal Risk and the Hopelessness but not with the Hamilton scales. These results stress the need to differentiate clinical subgroups of patients to assess the psychophysiology of depression, and indicate that patients who attempted suicide exhibit lower cortical resources and poorer cortical performance than patients without history of suicide attempt.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Psychiatry
Author, co-author :
Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Gonzalez Moreno, A.
Zaldua, I. U.
Ansseau, Marc ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
Suicidal behavior in depressive disorder: an event-related potential study.
Agren H (1980): Symptoms patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid: II, Suicide. Psychiatry Res 3:225-236.
American Psychological Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, revised. Washington DC: American Psychological Association Press.
Ashton H, Golding JF, Marsh VR, Thompson JW, Hassanyeh F, Tyrer SP (1988): Cortical evoked potentials and clinical rating scales as measures of depressive illness. Psychol Med 18:305-317.
Ashton CH, Marshall EF, Hassanyeh F, Marsh VR, Wright-Honari S (1994): Biological correlates of deliberate self-harm behaviour: A study of electroencephalographic; biochemical and psychological variables in parasuicide. Acta Psychiatr Scand 90:316, 323.
Bachneff SA, Engelsmann F (1980): Contingent negative variation, postimperative negative variation, and psychopathology. Biol Psychiatry 15:323-328.
Beck AT (1976): Cognitive Therapy and Emotional Disorders. New York: International Universities Press, 1976.
Beck AT, Steer RA, Kovacs M, Garisson M (1985): Hopelessness and eventual suicide: A 10-year prospective study of patients hospitalized with suicidal ideations. Am J Psychiatry 142:559-563.
Beck AT (1986): Hopelessness as a predictor of eventual suicide. In Mann JJ, Stanley M (eds), Psychobiology of Suicidal Behavior. Ann N Y Acad Sci 487:90-96.
Birbaumer N, Elbert T, Canavan AGM, Rockstroh B (1990): Slows potentials of the cerebral cortex and behavior. Physiol Rev 70:1-41.
Blackwood DHR, Whalley LJO, Christie JE (1987): Changes in auditory P3 event-related potential in schizophrenia and depression. Br J Psychiatry 150:154-160.
Bruder GE, Towey JP, Stewart JW, Friedman D, Tenke C, Quitkin FM (1991): Event-related potentials in depression: Influence of task, stimulus hemifield and clinical features on P300 latency. Biol Psychiatry 30:233-246.
Brunia CHM (1998): Movement and stimulus preceding negativity. Biol Psychol 26:165-178.
Callaway E (1991): Discussion: Towards a pharmacology of information processing. In Brunia CHM, Mulder G, Verbaten MN (eds): Event-Related Brain Research, EEG suppl. 42. Amsterdam: Elsevier, pp 173-176.
Donchin E, Karis D, Bashore TR, Coles MGH, Gratton G (1986): Cognitive psychophysiology and human information processing psychophysiology. In Cole MGH, Donchin E, Porges SW (eds): Systems, Processes and Applications. Amsterdam: Elsevier, pp 244-267.
El Massioui F, Lesèvre N (1988): Psychomotor retardation in depressed patients: an event-related study. Neurophysiol Clin 70:46-55.
Hansenne M, Pitchot W, Gonzalez-Moreno A, Gonzalez-Torrecilas J, Mirel J, Ansseau M (1994): Psychophysiological correlates of suicidal behavior in depression: Preliminary results. Neuropsychobiology 30:1-3.
Hansenne M, Pitchot W, Gonzalez-Moreno A, Papart P, Timsit-Berthier M, Ansseau M (1995): Catecholaminergic functions and P300 amplitude in depressed patients. Electroencephalogr Clin J 96:194-196.
Johnson R (1986): A triarchic model of P300 amplitude. Psychophysiology 23:367-384.
Johnson R (1993): On the neural generators of the P300 component of the event-related potential. Psychophysiology 30:90-97.
Klorman R, Brumaghim JT (1991): Stimulant drugs and ERPs. In Brunia CHM, Mulder G, Verbaten MN (eds): Event-Related Brain Research, EEG suppl. 42. Amsterdam: Elsevier, pp 135-141.
Kutcher SP, Blackwood DHR, Gaskell DF, Muir WJ, St Clair DM (1989): Auditory P300 does not differentiate borderline personality disorder from schizotypical personality disorder. Biol Psychiatry 26:766-774.
Levit RA, Sutton S, Zubin J (1973): Evoked potential correlates of information processing in psychiatrics patients. Psychol Med 3:487-494.
Macar F (1985): Time psychophysics and related models. In Michon JA, Jackson JL (eds): Time, Mind and Behavior. Heidelberg: Springer, pp 112-130.
McFarlane AC, Weber DL, Clark CR (1993): Abnormal stimulus processing in postraumatic stress disorder. Biol Psychiatry 34:311-320.
Papart P, Ansseau M, Devoitille J-M, Mantanus H, Timsit-Berthier M (1991): Contingent negative variation and the severity of depression. In Stefanis CN, Soldatos CR, Rabavilas P (eds): Psychiatry: A World Perspective, Vol 2. Amsterdam, pp 402-408.
Pfefferbaum A, Wenegrat BG, Ford JM (1984): Clinical application of P3 component of event-related potentials II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 59:104-124.
Pitchot W, Hansenne M, Gonzalez Moreno A, Ansseau M (1992): Suicidal behavior and growth hormone response to apomorphine test. Biol Psychiatry 31:1213-1219.
Plutchick R, van Praag HM, Conte HR, Pilard S (1989): Correlates of suicide and violence risk 1: The suicide risk measure. Compr Psychiatry 30:296-302.
Polich J (1992): On the clinical application of P300. Biol Psychiatry 31:647-649.
Raine A, Venables PH (1987): Contingent negative variation, P3 evoked potentials, and antisocial behavior. Psychophysiology 24:191-199.
Rockstroh B, Elbert T, Lutzenberger W, Birbaumer N (1982): Slow Brain Potentials and Behavior. Baltimore: Munich Urban and Schwarzenberg.
Rohrbaugh JW, Gaillard AWK (1983): Sensory and motor aspects of the contingent negative variation. In Gaillard AWK, Ritter W (eds): Tutorials in ERP's Research: Endogenous Components. Amsterdam: North Holland pp 269-310.
Rösler F, Manzey D, Sojka B (1985): Delineation of pharmacopsychological effects by means of endogenous event-related brain potentials: An exemplification with flupentixol. Neuropsychobiology 13:81-92.
Roth WT, Duncan CC, Pfefferbaum A, Timsit-Berthier M (1986): Applications of cognitive ERPs in psychiatric patients. In McCallum WC, Zappoli R, Denoth F (eds): Cerebral Psychophysiology: Study in Event-Related Potentials, EEG suppl 38. Amsterdam: Elsevier, pp 419-438.
Roth WT, Duncan CC, Pfefferbaum A, Timsit-Berthier M (1986): Applications of cognitive ERPs in psychiatric patients. In McCallum WC, Zappoli R, Denoth F (eds): Cerebral Psychophysiology: Study in Event-Related Potentials, EEG suppl. 38. Amsterdam: Elsevier, pp 419-438.
Roy A, Agren A, Pickar D (1988): Reduced CSF concentration of homovanillic acid and homovanillic acid to 5-hydroxyin-dolacetic acid ratio in depressed patients: Relationship to suicidal behavior and dexamethasone nonsuppression. Am J Psychiatry 143:1539-1545.
Roy A, Karoum F, Pollack S (1992): Marked reduction in indexes of dopamine metabolism among patients with depression who attempt suicide. Arch Gen Psychiatry 9:447-450.
Roy A, Pollack S (1994): Are cerebrospinal fluid or urinary monoamine metabolite measures stronger correlates of suicidal behavior in depression? Neuropsychobiology 29:164-167.
Santosh PJ, Malhotra S, Raghunathan M, Mehra YN (1994): A study of P300 in melancholic depression. Correlation with psychotic features. Biol Psychiatry 35:474-479.
Seligman MEP (1976): Depression and learned helplessness. In Friedman R, Katz M (eds): The Psychology of Depression: Contemporary Theory and Research. New York: Wiley, pp 83-113.
Statgraphics (1988): Statistical Graphics System by Statistical Graphics Corporation. STSC Inc, New York.
Tecce JJ (1972): Contingent negative variation and psychological processes in man. Psychol Bull 77:73-108.
Tecce JJ (1991): Dopamine and CNV: Studies of drugs, disease and nutrition. In Brunia CHM, Mulder G, Verbaten MN (eds): Event-Related Brain Research, EEG suppl. 42. Amsterdam: Elsevier, pp 153-164.
Thier P, Axmann D, Gierdke (1986): Slow brain potentials and psychomotor retardation in depression. Electroencephalogr Clin Neurophysiol 63:570-581.
Timsit-Berthier M, Mantanus H, Ansseau M, Devoitille J-M, Dal Mas A, Legros J-J (1987): Contingent negative variation in major depressive patients. In Johnson R, Rohrbaugh JW, Parasuraman R (eds): Current Trends in Event Related Potentials Research. Amsterdam: Elsevier, pp 761-771.
Timsit-Berthier M (1991): Contingent negative variation (CNV) in psychopharmacology. In Brunia CHM, Mulder G, Verbaten MN (eds): Event-Related Brain Research, EEG suppl. 42. Amsterdam: Elsevier, pp 142-152.
Towey J, Bruder G, Hollanger E, Friedman D, Erhan H, Liebowitz M, Sutton S (1990): Endogenous event-related potentials in obsessive-compulsive disorder. Biol Psychiatry 28:92-98.