Alcohol and withdrawal: from animal research to clinical issues

[en] The withdrawal syndrome in alcohol-dependent patients appears to be a major stressful event whose intensity increases with repetition of detoxifications according to a kindling process. Disturbances in the balance between excitatory and inhibitory neural processes are reflected in a perturbed physical state while disturbances in the balance between positive and negative reinforcements are reflected in a perturbed mood state. Our purpose is to link the different behavioral outcomes occurring during withdrawal with specific biological brain mechanisms from the animal to the human being. Better understanding of the various biological mechanisms underlying withdrawal from alcohol will be the key to design and to apply appropriate pharmaceutical management, together with appropriate therapy aimed at inducing protracted abstinence. (C) 2003 Elsevier Science Ltd. All rights reserved.

Disciplines :

Neurosciences & behavior

Author, co-author :

De Witte, P.

Pinto, Emmanuel ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Verbanck, P.

Language :

English

Title :

Alcohol and withdrawal: from animal research to clinical issues

Publication date :

May 2003

Journal title :

Neuroscience and Biobehavioral Reviews

ISSN :

0149-7634

eISSN :

1873-7528

Publisher :

Elsevier, United Kingdom

Volume :

Issue :

Pages :

189-197

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 July 2021

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216 (4 by ULiège)

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Scopus citations^®

170

Scopus citations^®
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165

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134

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