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Article (Scientific journals)
P300 event-related potential and serotonin-1A activity in depression.
Hansenne, Michel; Ansseau, Marc
1999In European Psychiatry, 14 (3), p. 143-7
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Keywords :
Adult; Antidepressive Agents/diagnostic use; Depressive Disorder, Major/diagnosis/metabolism; Electroencephalography; Event-Related Potentials, P300/physiology; Female; Humans; Male; Piperazines/diagnostic use; Prolactin/metabolism; Psychiatric Status Rating Scales; Reaction Time; Serotonin/metabolism; Serotonin Agonists/diagnostic use
Abstract :
[en] The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.40, P = 0.007 at Cz; r = -0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Psychiatry
Author, co-author :
Hansenne, Michel  ;  Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Ansseau, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
P300 event-related potential and serotonin-1A activity in depression.
Publication date :
1999
Journal title :
European Psychiatry
ISSN :
0924-9338
eISSN :
1778-3585
Publisher :
Elsevier Science, Paris, France
Volume :
14
Issue :
3
Pages :
143-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 October 2009

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