Article (Scientific journals)
Trace analysis of estrogenic compounds in surface and groundwater by ultra high performance liquid chromatography-tandem mass spectrometry as pyridine-3-sulfonyl derivatives
Glineur, Alex; Barbera, B.; Nott, K. et al.
2018In Journal of Chromatography. A, 1534, p. 43-54
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Keywords :
Aqueous matrices; Estrogenic compounds; Ion suppression; Pyridine-3-sulfonyl; Liquid chromatography-tandem mass spectrometry (LC-MS/MS); EU surface water Watch List; Groundwater; Surface water; Water pollution; Ultra-Trace; Environmental Monitoring
Abstract :
[en] Natural estrogens (estrone: E1, 17β-estradiol: E2, estriol: E3) and synthetic 17α-ethynylestradiol (EE2) are reported as strong endocrine disruptors even at extremely low concentrations. Therefore, the watch list from the European Commission regarding emerging aquatic pollutants recommended maximum detection limits of 0.035 ng/L for EE2 and 0.4 ng/L for E1 and E2. In this study, a UHPLC-ESI-MS/MS method allowing quantification of E1, E2, E3 and EE2 in aqueous matrices was developed. The analytes were derivatized using pyridine-3-sulfonyl chloride and a broad range of product ions were generated and their specificity was assessed by analyzing both surface and groundwater. At least two product ions for each estrogenic compound were proved to be specific and hence suitable for quantification and confirmation. In complex aqueous matrices, analyte responses were particularly affected by ion suppression. This phenomenon was reduced by optimizing the clean-up and selecting a suitable stationary phase for the chromatographic separation. The limits of quantification assessed in surface water with the optimized method ranged from 0.098 ng/L (EE2) to 2.73 ng/L (E3). © 2017 Elsevier B.V.
Disciplines :
Chemistry
Author, co-author :
Glineur, Alex ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Barbera, B.;  AgroBioChem Department, Laboratory of Chemical Analysis, University of Liège, Gembloux Agro-Bio Tech, Passage des Déportés 2, Gembloux, Belgium, La Société Wallonne des Eaux, Rue de la Concorde 41, Verviers, Belgium
Nott, K.;  La Société Wallonne des Eaux, Rue de la Concorde 41, Verviers, Belgium
Carbonnelle, P.;  La Société Wallonne des Eaux, Rue de la Concorde 41, Verviers, Belgium
Ronkart, S.;  La Société Wallonne des Eaux, Rue de la Concorde 41, Verviers, Belgium
Lognay, Georges ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Tyteca, Eva ;  AgroBioChem Department, Laboratory of Chemical Analysis, University of Liège, Gembloux Agro-Bio Tech, Passage des Déportés 2, Gembloux, Belgium
Language :
English
Title :
Trace analysis of estrogenic compounds in surface and groundwater by ultra high performance liquid chromatography-tandem mass spectrometry as pyridine-3-sulfonyl derivatives
Publication date :
2018
Journal title :
Journal of Chromatography. A
ISSN :
0021-9673
eISSN :
1873-3778
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
1534
Pages :
43-54
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
SPW, Service Public de Wallonie; SPW-DGO3
Available on ORBi :
since 25 June 2021

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