Article (Scientific journals)
Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression: An international, 6-week double-blind study
Lepine, J. P.; Altamura, C.; ANSSEAU, Marc et al.
2001In Human Psychopharmacology, 16 (3), p. 219-227
Peer Reviewed verified by ORBi
 

Files


Full Text
Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression.pdf
Author postprint (340.67 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Anxious symptoms; Major depressive disorder; Paroxetine; Tianeptine
Abstract :
[en] Tianeptine (37.5 mg/day) and paroxetine (20 mg/day) were compared in a population of depressive patients without past or current history of co-morbid anxiety and/or important anxiolytic treatment. In a 6-week, double blind trial, the special focus was on anxious symptoms. Both drugs showed good efficacy on depressive symptomatology, assessed with MADRS and HDRS, but no difference was detected between tianeptine and paroxetine, for any assessment criterion. Despite the choice of selected depressive patients, without any co-morbid anxious disorder, anxiety scale scores at inclusion (HAMA and BAS) were appreciable but correlated poorly with depressive scores. Both tianeptine and paroxetine improved the apparent anxious component in depression. Tolerability of both drugs was good, although significantly better with tianeptine. Thus tianeptine and paroxetine are effective and safe treatments for major depression and may also act directly on the anxious component of the psychopathology.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Lepine, J. P.;  Service de Psychiatrie, Hpital Fernand Widal, 200, rue du Faubourg St Denis, 75745 Paris Cedex 10, France
Altamura, C.;  Service de Psychiatrie, Hpital Fernand Widal, 200, rue du Faubourg St Denis, 75745 Paris Cedex 10, France
ANSSEAU, Marc ;  Université de Liège - ULg
Ayuso Gutierrez, Jose Luis;  Servicio de Psiquiatria, Hospital Clinico de San Carlos - Madrid
Bitter, Istvan;  Department of Psychiatry and Psychotherapy, Semmelweis Orvostudomanyi Egyetem - Budapest
Lader, Malcolm;  Clinical Pharmacology Section, lnstitute of Psychiatry, Decrespigny Park, Denmark Hill - London
Waintraub, Lionel;  Service de Psychiatrie, Centre Hospitalier Paul Brousse - Villejuif
Language :
English
Title :
Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression: An international, 6-week double-blind study
Publication date :
2001
Journal title :
Human Psychopharmacology
ISSN :
0885-6222
eISSN :
1099-1077
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
Volume :
16
Issue :
3
Pages :
219-227
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 June 2021

Statistics


Number of views
32 (1 by ULiège)
Number of downloads
300 (1 by ULiège)

Scopus citations®
 
40
Scopus citations®
without self-citations
39
OpenCitations
 
25

Bibliography


Similar publications



Contact ORBi