Impact of preoperative treatment with antidepressants and/or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme: a monocentric retrospective study

HARDY, Pierre-Yves; Bodson, Aurélie; de Harenne, Charlotte; HANS, Grégory; JORIS, Jean

doi:10.1080/00015458.2021.1940727

Article (Scientific journals)

Impact of preoperative treatment with antidepressants and/or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme: a monocentric retrospective study

HARDY, Pierre-Yves; Bodson, Aurélie; de Harenne, Charlotte et al.

2021 • In Acta Chirurgica Belgica

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/261121

DOI
10.1080/00015458.2021.1940727

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Keywords :

enhanced recovery; postoperative complications; antidepressants

Abstract :

[en] Abstract Background Preoperative use of antidepressants and anxiolytics was reported to increase length of hospital stay (LOS) and worsen surgical outcomes. However, the surgical procedures studied were seldom performed with an enhanced recovery programme (ERP). This study investigated whether these medications impaired postoperative recovery after colorectal surgery with an ERP. Methods The data of all patients scheduled for colorectal surgery between November 2015 and December 2019 prospectively included in our database were analysed. All the patients were managed with the same ERP. Demographic data, risk factors, incidence of postoperative complications, LOS, and adherence to the ERP were compared between patients with and without preoperative antidepressant and/or anxiolytic treatment. Results Of the 502 patients, 157 (31.3%) were treated with antidepressants and/or anxiolytics. They were older (65.7 vs. 59.5 years, p < 0.001), sicker (higher ASA physical status score, p = 0.001), and underwent surgery more frequently for cancer (73.9 vs. 56.8%, p < 0.001). Overall adherence to ERP (p = 0.99) and adherence to the postoperative items of ERP (p = 0.29), incidence of postoperative complications (35.7 vs. 33.2%, p = 0.61), and LOS (4 [2–7] vs. 4 [2–7], p = 0.99) were similar in the two groups. Conclusions Our findings suggest that preoperative treatment with antidepressants and/or anxiolytics does not worsen outcome after elective colorectal surgery with an ERP, does not impact adherence to ERP, and does not prolong LOS. ERP seems efficacious in patients treated with these medications, who should therefore not be excluded from this programme.

Disciplines :

Anesthesia & intensive care

Author, co-author :

HARDY, Pierre-Yves ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Bodson, Aurélie ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

de Harenne, Charlotte ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

HANS, Grégory ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

JORIS, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Language :

English

Title :

Impact of preoperative treatment with antidepressants and/or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme: a monocentric retrospective study

Publication date :

17 June 2021

Journal title :

Acta Chirurgica Belgica

ISSN :

0001-5458

Publisher :

Taylor & Francis

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 June 2021

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