Impact of preoperative treatment with antidepressants and/or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme: a monocentric retrospective study

HARDY, Pierre-Yves; Bodson, Aurélie; de Harenne, Charlotte; HANS, Grégory; JORIS, Jean

doi:10.1080/00015458.2021.1940727

Article (Scientific journals)

Impact of preoperative treatment with antidepressants and/or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme: a monocentric retrospective study

HARDY, Pierre-Yves; Bodson, Aurélie; de Harenne, Charlotte et al.

2021 • In Acta Chirurgica Belgica

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/261121

DOI
10.1080/00015458.2021.1940727

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

Impact of preoperative treatment with antidepressants and or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme a.pdf

Publisher postprint (1.52 MB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

enhanced recovery; postoperative complications; antidepressants

Abstract :

[en] Abstract Background Preoperative use of antidepressants and anxiolytics was reported to increase length of hospital stay (LOS) and worsen surgical outcomes. However, the surgical procedures studied were seldom performed with an enhanced recovery programme (ERP). This study investigated whether these medications impaired postoperative recovery after colorectal surgery with an ERP. Methods The data of all patients scheduled for colorectal surgery between November 2015 and December 2019 prospectively included in our database were analysed. All the patients were managed with the same ERP. Demographic data, risk factors, incidence of postoperative complications, LOS, and adherence to the ERP were compared between patients with and without preoperative antidepressant and/or anxiolytic treatment. Results Of the 502 patients, 157 (31.3%) were treated with antidepressants and/or anxiolytics. They were older (65.7 vs. 59.5 years, p < 0.001), sicker (higher ASA physical status score, p = 0.001), and underwent surgery more frequently for cancer (73.9 vs. 56.8%, p < 0.001). Overall adherence to ERP (p = 0.99) and adherence to the postoperative items of ERP (p = 0.29), incidence of postoperative complications (35.7 vs. 33.2%, p = 0.61), and LOS (4 [2–7] vs. 4 [2–7], p = 0.99) were similar in the two groups. Conclusions Our findings suggest that preoperative treatment with antidepressants and/or anxiolytics does not worsen outcome after elective colorectal surgery with an ERP, does not impact adherence to ERP, and does not prolong LOS. ERP seems efficacious in patients treated with these medications, who should therefore not be excluded from this programme.

Disciplines :

Anesthesia & intensive care

Author, co-author :

HARDY, Pierre-Yves ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Bodson, Aurélie ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

de Harenne, Charlotte ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

HANS, Grégory ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

JORIS, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Language :

English

Title :

Impact of preoperative treatment with antidepressants and/or anxiolytics on outcomes after colorectal surgery with an enhanced recovery programme: a monocentric retrospective study

Publication date :

17 June 2021

Journal title :

Acta Chirurgica Belgica

ISSN :

0001-5458

Publisher :

Taylor & Francis

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 June 2021

Statistics

Number of views

62 (4 by ULiège)

Number of downloads

4 (4 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Kantor ED, Rehm CD, Haas JS, et al. Trends in prescription drug use among adults in the United States from 1999 to 2012. JAMA. 2015; 314 (17): 1818.
Peck T, Wong A, Norman E., Anaesthetic implications of psychoactive drugs. Contin Educ Anaesth Crit Care Pain. 2010; 10 (6): 177–181.
Linnen H, Krampe H, Neumann T, et al. Depression and essential health risk factors in surgical patients in the preoperative anaesthesiological assessment clinic. Eur J Anaesthesiol. 2011; 28: 733–741.
Gehi A, Haas D, Pipkin S, et al. Depression and medication adherence in outpatients with coronary heart disease. Arch Intern Med. 2005; 165 (21): 2508.
Ciechanowski PS, Katon WJ, Russo JE., Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000; 160 (21): 3278–3285.
Kalkman JC, Visser K, Moen J, et al. Preoperative prediction of severe postoperative pain. Pain. 2003; 105 (3): 415–423.
Ruo B, Rumsfeld JS, Hlatky MA, et al. Depressive symptoms and health-related quality of life: the heart and soul study. JAMA. 2003; 290 (2): 215–221.
Balentine CJ, Hermosillo-Rodriguez J, Robinson CN, et al. Depression is associated with prolonged and complicated recovery following colorectal surgery. J Gastrointest Surg. 2011; 15 (10): 1712–1717.
Auerbach AD, Vittinghoff E, Maselli J, et al. Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery. JAMA Intern Med. 2013; 173 (12): 1075–1081.
Ward N, Scott Roth J, Lester CC, et al. Anxiolytic medication is an independent risk factor for 30-day morbidity or mortality after surgery. Surg (United States). 2015; 158 (2): 420–427.
Sutherland AM, Katznelson R, Clarke HA, et al. Use of preoperative antidepressants is not associated with postoperative hospital length of stay. Can J Anaesth. 2014; 61 (1): 27–31.
Kehlet H, Wilmore DW., Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008; 248 (2): 189–198.
Ljungqvist O, Scott M, Fearon KC., Enhanced recovery after surgery: a review. JAMA Surg. 2017; 152 (3): 292–298.
Greco M, Capretti G, Beretta L, et al. Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials. World J Surg. 2014; 38 (6): 1531–1541.
Aarts M-A, Rotstein OD, Pearsall EA, et al. Postoperative ERAS interventions have the greatest impact on optimal recovery. Ann Surg. 2018; 267 (6): 992–997.
Ljungqvist O, de Boer HD, Balfour A, et al. Opportunities and challenges for the next phase of enhanced recovery after surgery: a review. JAMA Surg. 2021.doi: 10.1001/jamasurg.2021.0586.
Joshi GP, Kehlet H., Postoperative pain management in the era of ERAS: an overview. Best Pract Res Clin Anaesthesiol. 2019; 33 (3): 259–267.
Meunier A, Sorce G, Hardy P-Y, et al. Comparison of outcome after right colectomy with an enhanced recovery programme in patients with inflammatory bowel disease and patients operated on for other conditions: a monocentric retrospective study. Int J Colorectal Dis. 2021; 36 (4): 757–763.
Hardy P-Y, Degesve M, Joris J, et al. Impact of preoperative anemia on outcomes of enhanced recovery program after colorectal surgery: a monocentric retrospective study. World J Surg. 2021.doi: 10.1007/s00268-021-06161-w.
Ripollés-Melchor J, Ramírez-Rodríguez JM, Casans-Francés R, for the POWER Study Investigators Group for the Spanish Perioperative Audit and Research Network (REDGERM), et al. Association between use of enhanced recovery after surgery protocol and postoperative complications in colorectal surgery: the postoperative outcomes within enhanced recovery after surgery protocol (POWER) study. JAMA Surg. 2019; 154 (8): 725–736.
von Elm E, Altman DG, Egger M, STROBE Initiative, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Epidemiology. 2007; 18 (6): 800–804.
Fiore JF, Castelino T, Pecorelli N, et al. Ensuring early mobilization within an enhanced recovery program for colorectal surgery: a randomized controlled trial. Ann Surg. 2017; 266 (2): 223–231.
Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications. Ann Surg. 2009; 250 (2): 187–196.
Jammer I, Wickboldt N, Sander M, European Society of Intensive Care Medicine, et al. Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol. 2015; 32 (2): 88–105.
Gustafsson UO, Scott MJ, Hubner M, et al. Guidelines for perioperative care in elective colorectal surgery: enhanced recovery after surgery (ERAS®) society recommendations: 2018. World J Surg. 2019; 43 (3): 659–695.
Alfonsi P, Slim K, Chauvin M, Société française de chirurgie digestive (SFCD), et al. French guidelines for enhanced recovery after elective colorectal surgery. J Visc Surg. 2014; 151 (1): 65–79.
Joris J, Hans G, Coimbra C, et al. Elderly patients over 70 years benefit from enhanced recovery programme after colorectal surgery as much as younger patients. J Visc Surg. 2020; 157 (1): 23–31.
Jackson NA, Gan T, Davenport DL, et al. Preoperative opioid, sedative, and antidepressant use is associated with increased postoperative hospital costs in colorectal surgery. Surg Endosc. 2020; 1: 3.
Vashishta R, Kendale SM., Relationship between preoperative antidepressant and antianxiety medications and postoperative hospital length of stay. Anesth Analg. 2019; 128: 248–255.
Jurt J, Slieker J, Frauche P, et al. Enhanced recovery after surgery: can we rely on the key factors or do we need the bel ensemble? World J Surg. 2017; 41 (10): 2464–2470.
Group EC., The impact of enhanced recovery protocol compliance on elective colorectal cancer resection. Ann Surg. 2015; 261: 1153–1159.
Grass F, Zhu E, Brunel C, et al. Crohn’s versus cancer: comparison of functional and surgical outcomes after right-sided resections. Dig Dis. 2021; 39: 106–112.
Srinath A, Young E, Szigethy E., Pain management in patients with inflammatory bowel disease: translational approaches from bench to bedside. Inflamm Bowel Dis. 2014; 20 (12): 2433–2449.
Graff LA, Walker JR, Bernstein CN., Depression and anxiety in iflammatory bowel disease: a review of comorbidity and management. Inflamm Bowel Dis. 2009; 15: 1105–1118.
Slieker J, Frauche P, Jurt J, et al. Enhanced recovery ERAS for elderly: a safe and beneficial pathway in colorectal surgery. Int J Colorectal Dis. 2017; 32 (2): 215–221.
Jørgensen CC, Madsbad S, Kehlet H, Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group. Postoperative morbidity and mortality in type-2 diabetics after fast-track primary total hip and knee arthroplasty. Anesth Analg. 2015; 120 (1): 230–238.