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Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now?

Parulski, Chloé; Jennotte, Olivier; Lechanteur, Anna et al.

2021 • In Advanced Drug Delivery Reviews, 175

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/261087

DOI
10.1016/j.addr.2021.05.020

PubMed
34029646

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Keywords :

Additive manufacturing; Critical process parameters; Pharmaceutics

Abstract :

[en] In recent years, fused deposition modeling has become one of the most used threedimensional printing technologies in the pharmaceutical field. The production of personalized dosage forms for individualized therapy and the modification of the drug release profile by the elaboration of complex geometries make fused deposition modeling a promising tool for small-scale production. However, fused deposition modeling has a considerable number of challenges to overcome. They are divided into three categories of parameters. Materialspecific parameters encompass the physicochemical properties of the filament, like thermal, mechanical and rheological properties. They determine the feasibility of the printing process. Operation-specific parameters relate to the processing conditions of printing, such as printing temperature and infill density, which have an influence on the final quality and on the dissolution behavior of the objects. The printer equipment is defined by the machine-specific parameters. Some modifications of this equipment also enhance the performance of the printing process. The aim of this review is to highlight the major fused deposition modeling critical process parameters in the pharmaceutical field and possible solutions in order to speed up the development of objects in the pharmaceutical market.

Research Center/Unit :

Center for Interdisciplinary Research on Medicines (CIRM)

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Parulski, Chloé ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Jennotte, Olivier ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Lechanteur, Anna ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Language :

English

Title :

Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now?

Alternative titles :

[fr] Défis de l'impression 3D à modélisation par dépôt fondu dans les applications pharmaceutiques: Où en sommes-nous à présent?

Publication date :

August 2021

Journal title :

Advanced Drug Delivery Reviews

ISSN :

0169-409X

eISSN :

1872-8294

Publisher :

Elsevier, Netherlands

Special issue title :

Additive Manufacturing in Pharmaceutical Product Design

Volume :

175

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

Development of new oral formulations produced by the hot melt extrusion technique coupled with 3D printing in order to increase the solubility of active molecules like BCSII

Funders :

FEDER - Fonds Européen de Développement Régional

Available on ORBi :

since 17 June 2021

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