Article (Scientific journals)
Plant flavonoids as modulators of the aryl hydrocarbon receptor
Goya-Jorge, Elizabeth; Jorge Rodríguez, María Elisa; Veitía, Maité Sylla-Iyarreta et al.
2021In Molecules, 26, p. 22315
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Keywords :
flavonoids; xenobiotics; phytochemicals; phytocompounds; functional food; Ah receptor; polyphenols; bioactive; dioxin receptor; transcription factor
Abstract :
[en] The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and diseases. Historically identified as a sensor of xenobiotics and mainly toxic substances, AhR has recently become an emerging pharmacological target in cancer, immunology, inflammatory conditions, and aging. Multiple AhR ligands are recognized, with plant occurring flavonoids being the largest group of natural ligands of AhR in the human diet. The biological implications of the modulatory effects of flavonoids on AhR could be highlighted from a toxicological and environmental concern and for the possible pharmacological applicability. Overall, the possible AhR-mediated harmful and/or beneficial effects of flavonoids need to be further investigated, since in many cases they are contradictory. Similar to other AhR modulators, flavonoids commonly exhibit tissue, organ, and species-specific activities on AhR. Such cellular-context dependency could be probably beneficial in their pharmacotherapeutic use. Flavones, flavonols, flavanones, and isoflavones are the main subclasses of flavonoids reported as AhR modulators. Some of the structural features of these groups of flavonoids that could be influencing their AhR effects are herein summarized. However, limited generalizations, as well as few outright structure-activity relationships can be suggested on the AhR agonism and/or antagonism caused by flavonoids.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Goya-Jorge, Elizabeth  ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Gestion de la qualité dans la chaîne alimentaire
Jorge Rodríguez, María Elisa;  Universidad Central "Marta Abreu" de las Villas > Department of Pharmacy > Professor
Veitía, Maité Sylla-Iyarreta;  Conservatoire National des Arts et Métiers (Cnam) > Equipe de Chimie Moléculaire du Laboratoire Génomique, Bioinformatique et Chimie Moléculaire (EA 7528) > Professor
Giner, Rosa M;  Universitat de València > Department of Pharmacology > Professor
Language :
English
Title :
Plant flavonoids as modulators of the aryl hydrocarbon receptor
Publication date :
16 April 2021
Journal title :
Molecules
eISSN :
1420-3049
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
26
Pages :
22315
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 722634 - PROTECTED - PROTECTion against Endocrine Disruptors; Detection, mixtures, health effects, risk assessment and communication.
Name of the research project :
PROTECTED - PROTECTion against Endocrine Disruptors; Detection, mixtures, health effects, risk assessment and communication
Funders :
CE - Commission Européenne [BE]
Available on ORBi :
since 12 June 2021

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