Régulation hypothalamique de la neurosécrétion de GnRH à la puberté

A higher pulsatile secretionof the gonadotropin-releasing hormone (GnRH) stimulates the pituitary - gonad axis upon puberty. Hypothalamic signals (glutamate, TGFα, GABA inhibitor) are playing a significant role in the activation of GnRH secretion. Sex steroids excepted, the experiments performed so far tend to demonstrate that leptin is one of th main peripheral signals. Environmental and nutritional, in particular, factors as well as genes (oct-2) are also involved in pubertal development.