Article (Scientific journals)
Robust switches in thalamic network activity require a timescale separation between sodium and T-type calcium channel activations
Jacquerie, Kathleen; Drion, Guillaume
2021In PLoS Computational Biology
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Keywords :
ion channel kinetics; modeling; brain states; neuromodulation; synaptic plasticity
Abstract :
[en] Switches in brain states, synaptic plasticity and neuromodulation are fundamental processes in our brain that take place concomitantly across several spatial and timescales. All these processes target neuron intrinsic properties and connectivity to achieve specific physiological goals, raising the question of how they can operate without interfering with each other. Here, we highlight the central importance of a timescale separation in the activation of sodium and T-type calcium channels to sustain robust switches in brain states in thalamic neurons that are compatible with synaptic plasticity and neuromodulation. We quantify the role of this timescale separation by comparing the robustness of rhythms of six published conductance-based models at the cellular, circuit and network levels. We show that robust rhythm generation requires a T-type calcium channel activation whose kinetics are situated between sodium channel activation and T-type calcium channel inactivation in all models despite their quantitative differences.
Disciplines :
Life sciences: Multidisciplinary, general & others
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Jacquerie, Kathleen  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Drion, Guillaume ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Language :
English
Title :
Robust switches in thalamic network activity require a timescale separation between sodium and T-type calcium channel activations
Publication date :
May 2021
Journal title :
PLoS Computational Biology
ISSN :
1553-734X
eISSN :
1553-7358
Publisher :
Public Library of Science, United States - California
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 07 June 2021

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