The emerging role of PET imaging in dementia.

[en] A compelling need in the field of neurodegenerative diseases is the development and validation of biomarkers for early identification and differential diagnosis. The availability of positron emission tomography (PET) neuroimaging tools for the assessment of molecular biology and neuropathology has opened new venues in the diagnostic design and the conduction of new clinical trials. PET techniques, allowing the in vivo assessment of brain function and pathology changes, are increasingly showing great potential in supporting clinical diagnosis also in the early and even preclinical phases of dementia. This review will summarize the most recent evidence on fluorine-18 fluorodeoxyglucose-, amyloid -, tau -, and neuroinflammation - PET tools, highlighting strengths and limitations and possible new perspectives in research and clinical applications. Appropriate use of PET tools is crucial for a prompt diagnosis and target evaluation of new developed drugs aimed at slowing or preventing dementia.

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Iaccarino, Leonardo

Sala, Arianna ; UniSR

Caminiti, Silvia Paola

Perani, Daniela

Language :

English

Title :

The emerging role of PET imaging in dementia.

Publication date :

2017

Journal title :

F1000Research

eISSN :

2046-1402

Publisher :

F1000 Research Ltd, London, United Kingdom

Volume :

Pages :

1830

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 June 2021

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