c-Fos expression predicts long-term social memory retrieval in mice.

Amygdala/metabolism; Animals; Hippocampus/metabolism; Male; Memory/physiology; Memory, Long-Term/physiology; Mice; Mice, Inbred C57BL; Olfactory Bulb/physiology; Prefrontal Cortex/physiology; Proto-Oncogene Proteins c-fos/metabolism; Smell/physiology; Social Behavior; Contextual integration; Long-term social memory; Random Forest; Top-down modulation; c-Fos

Abstract :

[en] The way the rodent brain generally processes socially relevant information is rather well understood. How social information is stored into long-term social memory, however, is still under debate. Here, brain c-Fos expression was measured after adult mice were exposed to familiar or novel juveniles and expression was compared in several memory and socially relevant brain areas. Machine Learning algorithm Random Forest was then used to predict the social interaction category of adult mice based on c-Fos expression in these areas. Interaction with a familiar co-specific altered brain activation in the olfactory bulb, amygdala, hippocampus, lateral septum and medial prefrontal cortex. Remarkably, Random Forest was able to predict interaction with a familiar juvenile with 100% accuracy. Activity in the olfactory bulb, amygdala, hippocampus and the medial prefrontal cortex were crucial to this prediction. From our results, we suggest long-term social memory depends on initial social olfactory processing in the medial amygdala and its output connections synergistically with non-social contextual integration by the hippocampus and medial prefrontal cortex top-down modulation of primary olfactory structures.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Lüscher Dias, Thomaz

Fernandes Golino, Hudson

De Moura Oliveira, Vinicius Elias ; Université de Liège - ULiège > Neurosciences-Neuroendocrinology

Dutra Moraes, Márcio Flávio

Schenatto Pereira, Grace

Language :

English

Title :

c-Fos expression predicts long-term social memory retrieval in mice.

Publication date :

2016

Journal title :

Behavioural Brain Research

ISSN :

0166-4328

eISSN :

1872-7549

Publisher :

Elsevier, Netherlands

Volume :

313

Pages :

260-271

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 31 May 2021

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2 (1 by ULiège)

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