Estradiol effect on short-term object memory under hypocholinergic condition.

Acetylcholine/metabolism; Animals; Estradiol/pharmacology; Estrogens/pharmacology; Female; Hippocampus/drug effects/metabolism; Male; Memory Disorders/drug therapy/metabolism; Memory, Short-Term/drug effects/physiology; Mice, Transgenic; Nootropic Agents/pharmacology; Ovariectomy; RNA, Messenger/metabolism; Receptors, Estrogen/metabolism; Recognition, Psychology/drug effects/physiology; Sex Factors; Vesicular Acetylcholine Transport Proteins/deficiency/genetics; Acetylcholine; Estradiol; Estrogen receptors; Object recognition memory

Abstract :

[en] Estrogens positively affect object recognition memory (ORM). However, whether this effect rely on acetylcholine is unknown. Here we investigated if 17β-estradiol (E2) would be able to recover ORM deficits in animals with decreased expression of the Vesicular Acetylcholine Transporter (VAChT KD(HET)). We found that E2 improved short-term ORM (STM) in VAChT KD(HET) male and in OVX female mutant mice. However, E2 did not recover long-term (LTM) ORM in both sexes. Next, we tested whether hippocampal ERs activation could also rescue STM in mutant mice. Our results showed that ERα seems to be both sufficient and necessary for STM consolidation in female VAChT KD(HET). Differently, in male, both ERα and ERβ activation recovered STM. In addition, we tested whether mRNA level of estrogen receptors (ER) is also sensitive to VAChT expression. Female mutant mice showed lower levels of ER alpha (ERα) mRNA in the hippocampus, while no differences in male were observed. Together, our results showed that under hypocholinergic function, E2 improve short-term object recognition in both male and female. Furthermore, we showed that changes in VAChT expression might potentially modulate hippocampal ERα expression in a sex-dependent-manner.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Pereira, Luciana M.

Guimarães, Isabella M.

De Moura Oliveira, Vinicius Elias ; Université de Liège - ULiège > Neurosciences-Neuroendocrinology

Bastos, Cristiane P.

Ribeiro, Fabíola M.

Prado, Vânia F.

Prado, Marco A. M.

Pereira, Grace S.

Language :

English

Title :

Estradiol effect on short-term object memory under hypocholinergic condition.

Publication date :

2018

Journal title :

Brain Research Bulletin

ISSN :

0361-9230

eISSN :

1873-2747

Publisher :

Elsevier, Netherlands

Volume :

140

Pages :

411-417

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 31 May 2021

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