Animal models of social stress: the dark side of social interactions.

Animals; Behavior, Animal/physiology; Humans; Hypothalamo-Hypophyseal System/metabolism; Models, Animal; Oxytocin/metabolism; Pituitary-Adrenal System/metabolism; Social Behavior; Stress, Psychological/metabolism/psychology; Vasopressins/metabolism; Social stress; aggression; chronic subordinate colony housing; oxytocin; social fear; vasopressin

Abstract :

[en] Social stress occurs in all social species, including humans, and shape both mental health and future interactions with conspecifics. Animal models of social stress are used to unravel the precise role of the main stress system - the HPA axis - on the one hand, and the social behavior network on the other, as these are intricately interwoven. The present review aims to summarize the insights gained from three highly useful and clinically relevant animal models of psychosocial stress: the resident-intruder (RI) test, the chronic subordinate colony housing (CSC), and the social fear conditioning (SFC). Each model brings its own focus: the role of the HPA axis in shaping acute social confrontations (RI test), the physiological and behavioral impairments resulting from chronic exposure to negative social experiences (CSC), and the neurobiology underlying social fear and its effects on future social interactions (SFC). Moreover, these models are discussed with special attention to the HPA axis and the neuropeptides vasopressin and oxytocin, which are important messengers in the stress system, in emotion regulation, as well as in the social behavior network. It appears that both nonapeptides balance the relative strength of the stress response, and simultaneously predispose the animal to positive or negative social interactions.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Masis-Calvo, Marianela

Schmidtner, Anna K.

De Moura Oliveira, Vinicius Elias ; Université de Liège - ULiège > Neurosciences-Neuroendocrinology

Grossmann, Cindy P.

de Jong, Trynke R.

Neumann, Inga D.

Language :

English

Title :

Animal models of social stress: the dark side of social interactions.

Publication date :

2018

Journal title :

Stress (Amsterdam, Netherlands)

ISSN :

1025-3890

eISSN :

1607-8888

Volume :

Issue :

Pages :

417-432

Peer reviewed :

Peer reviewed

European Projects :

FP7 - 602407 - FEMNAT-CD - Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing

Funders :

CE - Commission Européenne [BE]

Available on ORBi :

since 31 May 2021

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