Article (Scientific journals)
Comparison study of oropharyngeal microbiota in case of bronchial asthma and chronic obstructive pulmonary disease in different severity levels
Ogorodova, L. M.; Fedosenko, S. V.; Popenko, A. S. et al.
2015In Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 70 (6), p. 669-678
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Keywords :
Bronchial asthma; Chronic obstructive pulmonary disease; Metagenome; Microbiota; Pulmonary Disease, Chronic Obstructive; Adult; Aged; Asthma; Bacteriological Techniques; Female; Humans; Male; Middle Aged; Oropharynx; Severity of Illness Index; Statistics as Topic
Abstract :
[en] Backgraund: The result of comparative study of oropharyngeal microbiota taxonomic composition in patients with different severity level of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) is presented in this paper. Aims: To compare oropharyngeal microbiota composition in case of bronchial asthma and chronic obstructive pulmonary disease in different severity levels. Metods: 138 patients, 50 with BA and 88 with COPD were studied. For each patient was collected anamnesis vitae, swab from the back of the throat and performed physical examination. Highthroughput 16S ribosomal RNA gene sequencing and bioinformatic analysis was employed to characterize the microbial communities. Results: As a result of the study was found a number of differences on various taxonomic levels in microbiota's composition within group of patients with different severity level of BA and group of patients with different severity level of COPD and between those groups. COPD patients with GOLD 1-2 in comparison with GOLD 3-4 patiens are marked by prevalence of species Brevibacterium aureum, genus Scardovia, Coprococcus, Haemophilus, Moryella, Dialister, Paludibacter and decrease of Prevotella melaninogenica species. BA patients with severe uncontrolled asthma in comparison with patients which have mild persistent asthma are marked by decrease of Prevotella and increase of species Bifidobacterium longum, Prevotella nanceiensis, Neisseria cinerea, Aggregatibacter segnis and genus Odoribacter, Alloiococcus, Lactobacillus, Megasphaera, Parvimonas, Sneathia. Patient's microbiota in BA group in comparison with COPD group is characterized by the prevalence of Prevotella melaninogenica and genus Selenomonas, Granulicatella ? Gemella, and decrease of Prevotella nigrescens, Haemophilus influenza and genus Aggregatibacter, Alloiococcus, Catonella, Mycoplasma, Peptoniphilus ? Sediminibacterium. There are no differences between microbiota composition in case of severe uncontrolled BA and very severe COPD. Conclusion: Lack of differences in oropharyngeal microbiota taxonomic composition between patients with severe uncontrolled BA and very severe COPD allow us to suggest a similarity of bronchopulmonary system condition in case of diseases' severe stages.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Ogorodova, L. M.;  Siberian State Medical University, Tomsk, Russian Federation
Fedosenko, S. V.;  Siberian State Medical University, Tomsk, Russian Federation
Popenko, A. S.;  Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation
Petrov, Viacheslav ;  Central Research Laboratory, Siberian State Medical University, Tomsk, Russian Federation
Tyakht, A. V.;  Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation
Saltykova, I. V.;  Siberian State Medical University, Tomsk, Russian Federation
Deev, I. A.;  Siberian State Medical University, Tomsk, Russian Federation
Kulikov, E. S.;  Siberian State Medical University, Tomsk, Russian Federation
Kirillova, N. A.;  Siberian State Medical University, Tomsk, Russian Federation
Govorun, V. M.;  Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation, Kazan Federal University, Kazan, Russian Federation
Kostryukova, E. S.;  Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation, Kazan Federal University, Kazan, Russian Federation
Language :
Russian
Title :
Comparison study of oropharyngeal microbiota in case of bronchial asthma and chronic obstructive pulmonary disease in different severity levels
Publication date :
2015
Journal title :
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
ISSN :
0869-6047
Publisher :
Izdatel'stvo Meditsina
Volume :
70
Issue :
6
Pages :
669-678
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 May 2021

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