[en] Background: Despite the efforts of scientific community the data available on the correlation between emotional-affective symptoms of Parkinson's disease and changes in microbiome is still scarce. Deeper studies of nonmotor symptoms evident in premotor stages of the disease and the reciprocal influence of microbiota may help to understand the etiology and pathogenesis of PD neurodegeneration better. The aim of the study was to discover the relations between emotional-affective disorders prevalent in PD population and changes in gut microbiota composition. Methods:51 patient diagnosed with PD participated in the study. Every participant's emotional-affective state was examined using Beck's Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS). Taxonomic richness of microbiome was studied using 16S ribosomal RNA gene sequencing, bioinformatics, and statistical analysis. Results: Anxiety and depression are prevalent affective disorders in patients with PD. In our study, most of the subjects demonstrated certain anxiety and depression. Taxonomic diversity of gut microbiota in BP was increasing with the increase in anxiety levels, reaching the maximum in the group with subclinical anxiety, and decreasing in the group with clinically significant anxiety disorder. At the species level, patients with clinically significant anxiety had higher abundance of Clostridium clariflavum compared to the anxiety-free patients. Patients with moderate depression were characterized by the higher prevalence of Christensenella minuta, Clostridium disporicum, and Oscillibacter valericigenes compared to subjects without depression or with mild depression. Conclusion: The data we received in our study allow better understanding of PD pathogenesis.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Alifirova, V. M.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Zhukova, N. G.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Zhukova, I. A.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Mironova, Yu S.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Petrov, Viacheslav ; Central Research Laboratory, Siberian State Medical University, Tomsk, Russian Federation
Izhboldina, O. P.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Titova, M. A.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Latypova, A. V.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Nikitina, M. A.; Department of Neurology and Neurosurgery, Siberian State Medical University, Tomsk, Russian Federation
Dorofeeva, Y. B.; Central Research Laboratory, Siberian State Medical University, Tomsk, Russian Federation
Saltykova, I. V.; Central Research Laboratory, Siberian State Medical University, Tomsk, Russian Federation
Tyakht, A. V.; Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation
Kostryukova, E. S.; Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russian Federation
Sazonov, A. E.; Central Research Laboratory, Siberian State Medical University, Tomsk, Russian Federation, Lomonosov Moscow State University, Moscow, Russian Federation
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