A role of the gastrointestinal tract microbiota in the pathogenesis of Parkinson’s disease

Microbiota; Microflora; Neurodegenerative diseases; Parkinson’s disease; The gastrointestinal tract; Article; Parkinson disease; Brain; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Phylogeny

Abstract :

[en] Microbiota is a community of microorganisms, viruses, protozoa, colonizing the gut. There are tight phylogenetic relationships between the gut microbiota and the human body, the disturbance of which may lead to the CNS dysfunction as well as to the development of neurodegenerative diseases. This review focuses on general and specific aspects of the influence of gut microbiota on the pathogenesis of Parkinson’s disease (PD). Current theories and models of the relationship between microbiota and brain structures in PD are presented with a specific focus on neurochemical and immunological aspects of the problem. © 2016, Media Sphera. All rights reserved.

Disciplines :

Neurology

Author, co-author :

Alifirova, V. M.; Siberian State Medical University, Tomsk, Russian Federation

Zhukova, N. G.; Siberian State Medical University, Tomsk, Russian Federation

Zhukova, I. A.; Siberian State Medical University, Tomsk, Russian Federation

Latypova, A. V.; Siberian State Medical University, Tomsk, Russian Federation

Titova, M. A.; Siberian State Medical University, Tomsk, Russian Federation

Mironova, Y. S.; Siberian State Medical University, Tomsk, Russian Federation

Izhboldina, O. P.; Siberian State Medical University, Tomsk, Russian Federation

Nikitina, M. A.; Siberian State Medical University, Tomsk, Russian Federation

Petrov, Viacheslav ; Siberian State Medical University (SSMU), 2, Moscow Trakt, Tomsk, 634050, Russian Federation

Language :

Russian

Title :

A role of the gastrointestinal tract microbiota in the pathogenesis of Parkinson’s disease

Publication date :

2016

Journal title :

Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova

ISSN :

1997-7298

Publisher :

Media Sphera Publishing Group

Volume :

116

Issue :

Pages :

174-179

Peer reviewed :

Peer reviewed

Available on ORBi :

since 27 May 2021

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