Opisthorchiasis and the Microbiome

Bile; Liver fluke; Microbiome; Microbiota; Opisthorchiasis; Aggregatibacter; Article; Erysipelotrichaceae; Eubacteriaceae; Fasciola hepatica; Helicobacter infection; Helicobacter pylori; Klebsiella; Lachnospiraceae; Lactobacillaceae; Lactobacillus; Opisthorchis felineus; Opisthorchis viverrini; Porphyromonadaceae; Ruminococcaceae; Treponema; Animals; Biodiversity; Disease Models, Animal; Humans

Abstract :

[en] The liver flukes Opisthorchis viverrini, O. felineus, and Clonorchis sinensis are closely related fish-borne trematodes endemic in East Asia, Eurasia, and Siberia. Following ingestion, the parasites locate to the biliary tree, where chronic infection frequently leads to cholangiocarcinoma (CCA). Infection with C. sinensis or O. viverrini is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Infection with O. felineus may also be carcinogenic. The mechanism(s) by which infection with these liver flukes culminates in CCA remain elusive, although they are likely to be multi-factorial. Not yet well studied is the influence of opisthorchiasis on the microbiome of the host despite reports that helminth parasites are capable of affecting the microbiome, potentially modulating gastrointestinal inflammation in response to the appearance of pathogenic strains of bacteria. Here, we review recent findings related to opisthorchiasis and the microbiome and related issues. In the hamster, a tractable model of infection with liver fluke and of infection-induced biliary morbidity and CCA, infection with O. viverrini perturbs the microbiome of the gastrointestinal tract, including increasing numbers of Lachnospiraceae, Ruminococcaceae, Lactobacillaceae, and others, while decreasing Porphyromonadaceae, Erysipelotrichaceae, and Eubacteriaceae. In addition, a complex microbial community associates with the parasites within the biliary tree, including Helicobacter pylori and related bacteria. Moreover, higher rates of infection with Helicobacter occur in Thailand in persons with opisthorchiasis in a liver fluke infection intensity-dependent manner. Experimental infection of hamsters with Opisthorchis felineus results in increased alpha diversity of the microbiota diversity in the biliary tract. In humans, infection with O. felineus modifies the composition of the biliary microbiome, with increasing numbers of species of Klebsiella, Aggregatibacter, Lactobacillus, Treponema, and others. Several phylotypes of Archaea occurred solely in bile from persons infected with O. felineus. © 2018 Elsevier Ltd

Disciplines :

Immunology & infectious disease

Author, co-author :

Saltykova, I. V.; Siberian State Medical University, Central Research Laboratory, Tomsk, Russian Federation

Petrov, Viacheslav ; Siberian State Medical University (SSMU), 2, Moscow Trakt, Tomsk, 634050, Russian Federation

Brindley, P. J.; Department of Microbiology, Immunology & Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC, United States

Language :

English

Title :

Opisthorchiasis and the Microbiome

Publication date :

2018

Journal title :

Advances in Parasitology

ISSN :

0065-308X

Publisher :

Academic Press

Volume :

102

Pages :

1-23

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

NIH - National Institutes of Health
NCI - National Cancer Institute
NIAID - National Institute of Allergy and Infectious Diseases
NCI - National Computational Infrastructure
RSF - Russian Science Foundation

Commentary :

9780128151914

Available on ORBi :

since 27 May 2021

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