Helminths and intestinal microbiota interaction: Role in the development of noncommunicable diseases

[en] There is an increase in the prevalence of chronic, noncommunicable diseases, including allergic and autoimmune diseases in developed countries. In this regard, the study of factors modifying the population's immune response is very important. According to the "old friends" hypothesis , insufficiency of infectious stimulation and decrease in prevalence of helminthiasis are associated with development of noncommunicable diseases. Studies revealed that intestinal parasites modulate the host immune response and alter susceptibility to immunological diseases. It is suggested that one of the pathogenetic mechanisms of immune response modulation by parasites is an increase in the content of gastrointestinal bacteria with anti-inflammatory effect. Advanced technologies of microorganism identification provide a deep insight into the microbiota in different pathologies. The study of changes in the intestine and bile microbiota of the host in helminthiases provides new possibilities for prevention, diagnosis and control of such conditions as chronic inflammatory bowel diseases and allergic diseases. The purpose of this review is to analyze current experimental and clinical data on intestinal microbiota in helminth infections and possible association with development of chronic noncommunicable diseases. © 2019 Siberian State Medical University. All rights reserved.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Sokolova, T. S.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Fedorova, O. S.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Saltykova, I. V.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Petrov, Viacheslav ; Siberian State Medical University (SSMU), 2, Moscow Trakt, Tomsk, 634050, Russian Federation

Fedotova, M. M.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Kovshirina, Y. V.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Deev, I. A.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Ogorodova, L. M.; Division of Intermediate-Level Pediatrics with A Course of Childhood Diseases, Siberian State Medical University (SSMU), 2 Moscow Trakt, Tomsk, 634050, Russian Federation

Language :

Russian

Title :

Helminths and intestinal microbiota interaction: Role in the development of noncommunicable diseases

Publication date :

2019

Journal title :

Bulletin of Siberian Medicine

ISSN :

1682-0363

eISSN :

1819-3684

Publisher :

Siberian State Medical University

Volume :

Issue :

Pages :

214-225

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

RFBR - Russian Foundation for Basic Research
RSF - Russian Science Foundation

Funding number :

Russian Science Foundation, RSF: 18-75-00036

Available on ORBi :

since 27 May 2021

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