Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates SARS-CoV-2 on N95 respirators and medical masks with maintenance of integrity and fit
Lendvay, Thomas Sean; Chen, J.; Harcourt, B.H.et al.
2021 • In Infection Control and Hospital Epidemiology
Haubruge, Eric ; Université de Liège - ULiège > Département GxABT > Gestion durable des bio-agresseurs
Thiry, Etienne ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales
Heyne, B.
Laperre, J.
Page, K.
Cui, Y.
Clark, T.
Smits, S.J.
Parker, R.
Timm, E.
Mores, C.N.
Ludwig-Begall, Louisa ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales
Macia, N.
Faris, P.
Evans, D.
Chu, L.F.
Gallagher, T.
Jolois, O.
Patel, A.
Molloy-Simard, V.
Homdayjanakul, K.
Sahni, J.
Tritsch, S.R.
Wielick, Constance ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales
Simmons, S.
Mackie, C.
Mayo, M.
Lemyre, J.C.
Wagner, T.
Dams, Lorène ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Département des maladies infectieuses et parasitaires (DMI)
Addressing personal protective equipment (PPE) decontamination : methylene blue and light inactivates SARS-CoV-2 on N95 respirators and medical masks with maintenance of integrity and fit
Rational use of personal protective equipment for coronavirus disease (COVID-19) and considerations during severe shortages. World Health Organization website. https://www.who.int/publications/i/item/rational-useof-personal-protective-equipment-for-coronavirus-disease-(covid-19)-andconsiderations-during-severe-shortages. Published December 23, 2020. Accessed May 3, 2021.
Decontamination systems for personal protective equipment EUAs, 2020; 1-4. US Food and Drug Administration website. https://www. fda.gov/medical-devices/coronavirus-disease-2019-covid-19-emergencyuse-authorizations-medical-devices/decontamination-systems-personalprotective-equipment-euas. Accessed December 20, 2020.
Richter W, Hofacre K, Willenberg Z. Final Report for the Bioquell hydrogen peroxide vapor (HPV) decontamination for reuse of N95 respirators, Battelle. US Food and Drug Administration website. https://www.fda. gov/media/136386/download. Published 2016. Accessed April 24, 2021.
Burki, T. Global shortage of personal protective equipment. Lancet Inf Dis 2020; 20:785-786.
Nkengasong, JN, Mankoula W. Looming threat of COVID-19 infection in Africa: act collectively, and fast. Lancet 2020;395:841-842.
Costa L, Faustino MAF, Neves MGPMS, Cunha Â, Almeida A. Photodynamic inactivation of mammalian viruses and bacteriophages. Viruses 2012;4:1034-1074.
Seghatchian J, Walker WH, Reichenber S. Updates on pathogen inactivation of plasma using Theraflex methylene blue system. Transfus Apher Sci 2008;38:271-280.
Eickmann M, Gravemann U, Handke W, et al. Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively. Transfusion 2018;58:2202-2207.
Eickmann M, Gravemann U, Handke W, et al. Inactivation of three emerging viruses-severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus-in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light. Vox Sanguinis 2020;115:146-151.
Duan K, Liu B, Li C, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Nat Acad Sci 2020;117:9490-9496.
Bergman MS, Viscusi DJ, Zhuang Z, et al. Impact of multiple consecutive donnings on filtering facepiece respirator fit. Am. J. Infect. Control 2012;40:375-380.
Boscarino JA, Logan HL, Lacny JJ, Gallagher TM. Envelope protein palmitoylations are crucial for murine coronavirus assembly. J Virol 2008;82: 2989-2999.
Pensaert M, Callebaut P, Vergote J. Isolation of a porcine respiratory, nonenteric coronavirus related to transmissible gastroenteritis. Veterinary Qrtrly 1986;8:257-261.
Wesley RD, Hill HT, Biwer JD. Evidence for a porcine respiratory coronavirus, antigenically similar to transmissible gastroenteritis virus, in the United States. J Vet Diagn Investig 1990;2:312-317.
Cox E, Hooyberghs J, Pensaert MB. Sites of replication of a porcine respiratory coronavirus related to transmissible gastroenteritis virus. Res Vet Sci 1990;48:165-169.
National Institute for Occupational Safety and Health. Assessment of filter penetration performance and fit for decontaminated N95 respirators. NPPTL Assessment to Support the COVID-19 Response National Personal Protective Technology Laboratory National Institute for Occupational Safety and Health Centers for Disease Control and Prevention. Centers for Disease Control and Prevention website. https://www.cdc.gov/niosh/npptl/respirators/testing/pdfs/NIOSHApproved_ Decon_TestPlan10.pdf. Published 2020. Access May 18, 2021.
ASTM F2100-19e1: Standard Specification for Performance of Materials used in Medical Face Mask. ASTM International website. https://www. astm.org/DATABASE.CART/HISTORICAL/F2100-19E1.htm. Published 2019. Accessed May 18, 2021.
NIOSH. Determination of exhalation resistance test, air-purifying respirators standard testing procedure (STP). Centers for Disease Control and Prevention website. https://www.cdc.gov/niosh/npptl/stps/pdfs/TEB-APRSTP-0003-508.pdf. Published 2019. Accessed December 20, 2020.
NIOSH. Determination of Inhalation Resistance Test, Air-Purifying Respirators Standard Testing Procedure (STP) Revision 2.3. Centers for Disease Control and Prevention website. https://www.cdc.gov/niosh/ npptl/stps/pdfs/TEB-APR-STP-0007-508.pdf. Published 2019. Accessed May 3, 2021.
FDA letter, June 6, 2020. US Food and Drug Administration website. https:// www.fda.gov/media/136976/download. Accessed December 20, 2020.
Bergman MS, Zhuang Z, Hanson D, et al. Development of an advanced respirator fit-test headform. J Occupat Environ Hygiene 2014; 11: 117-125.
Perdrau JR Charles T. The photodynamic action of methylene blue on bacteriophage. Proc R Soc Lond 1933;112277-112287.
Organización Mundial de la Salud (OMS). World health organization model list of essential medicines. Mental and Holistic Health: Some International Perspectives. 2019;21:119-134.
Implementing filtering facepiece respirator (FFR) reuse, including reuse after decontamination, when there are known shortages of N95 respirators. Centers for Disease Control and Prevention website. https://www.cdc.gov/ coronavirus/2019-ncov/hcp/ppe-strategy/decontamination-reuse-respirators. html. Published 2020. Accessed December 20, 2020.
Degesys NF, Wang RC, Kwan E, Fahimi J, Noble JA, Raven MC. Correlation between N95 extended use and reuse and fit failure in an emergency department. JAMA 2020;324:94.
Lieu A, Mah J, Zanichelli V, Exantus RC, Longtin Y. Impact of extended use and decontamination with vaporized hydrogen peroxide on N95 respirator fit. Am J Infect Control 2020;48:1457-1461.
Rengelshausen J, Burhenne J, Fröhlich M, et al. Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria. Eur J Clin Pharmacol 2004;60:709-15.
Krespi YP, Kizhner V. Laser-assisted nasal decolonization of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus. Am J Otolaryngol Head Neck Med Surg 2012;33:572-575.