[en] OBJECTIVE: To compare WHO first-line antiretroviral therapy (ART) with nonnucleoside reverse transcriptase inhibitors (NNRTI)-based regimen with a boosted protease inhibitor (bPI) regimen in a resource-limited setting regarding treatment outcome and emergence of drug resistance mutations (DRMs). METHODS: Treatment-naive adults were randomized to nevirapine (NVP) or ritonavir-boosted lopinavir (LPV/r) regimens each in combination with tenofovir (TDF)/emtricitabine (FTC) or zidovudine (ZDV)/lamivudine (3TC). Primary endpoint was the incidence of therapeutical (clinical and/or virologic) failure at week 48 with follow-up till week 96. RESULTS: Four hundred and twenty-five patients (120 men; 305 women) received at least one dose of the study drug. mITT analysis showed no difference in proportion of therapeutical failure between treatment arms [67/209 (32%) in NVP vs. 63/216 (29%) LPV/r at week 48 (P = 0.53); 88/209 (42%) in NVP vs. 83/216 (38%) in LPV/r at week 96 (P = 0.49)]. Per-protocol analysis demonstrated significantly more virologic failure with NVP than with LPV/r regimens [at week 48: 19/167 (11%) vs. 7/166 (4%), P = 0.014; at week 96: 27/158 (17%) vs. 13/159 (8%), P = 0.019)]. Drug resistance mutations to NNRTI were detected in 19 out of 22 (86.3%) and dual-class resistance to nucleoside reverse transcriptase inhibitor (NRTI) and NNRTI in 15 out of 27 (68.2%) of NVP failing patients. K65R mutation was present in seven out of 14 patients failing NVP-TDF/FTC regimen. No major protease inhibitor-DRM was detected among LPV/r failing patients. Discontinuation for adverse events was similar between treatment groups. CONCLUSION: In resource-limited settings, first-line NNRTI-NRTI regimen as compared with bPI-based regimen provides similar outcome but is associated with a significantly higher number of virologic failure and resistance mutations in both classes that jeopardize future options for second-line therapy.
Disciplines :
Immunology & infectious disease
Author, co-author :
Clumeck, Nathan; Saint-Pierre University Hospital, 1000 Brussels, Belgium
Mwamba, Claude; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
Kabeya, Kabamba; Saint-Pierre University Hospital, 1000 Brussels, Belgium
Matanda, Serge; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
VAIRA, Dolorès ; Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Necsoi, Coca; Saint-Pierre University Hospital, 1000 Brussels, Belgium
Kadiebwe, David; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
Delforge, Marc; Saint-Pierre University Hospital, 1000 Brussels, Belgium
Kasamba, Eric; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
Milolo, Chantal; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
Ilunga, Joe; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
Kapend, Lievin; Lubumbashi Network & PNMLS, Bureau de Coordination PNMLS/ Katanga, Avenue Likasi, Lubumbashi, Congo RDC
Language :
English
Title :
First-line antiretroviral therapy with nevirapine versus lopinavir-ritonavir based regimens in a resource-limited setting
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