Relationship between smoking and the incidence of sarcopenia: The SarcoPhAge cohort

[en] Introduction: The association of tobacco use and incidence of muscle impairments has not been extensively explored in research. In this study, the relationship between smoking and the incidence of sarcopenia is investigated. Methods: The present longitudinal study used data from the Sarcopenia and Physical Impairment with advancing Age (SarcoPhAge) cohort, which includes older adults aged 65 years. All individuals with follow-up data on muscle health were included in this post hoc analysis. A diagnosis of sarcopenia was established, at each year of follow-up, according to the European Working Group on Sarcopenia in older People 2 (EWGSOP2) criteria. A sensitivity analysis was performed using other diagnostic criteria for sarcopenia. The smoking status and the number of cigarettes smoked per day were self-reported. The relationship between smoking status or the number of cigarettes smoked per day and the incidence of sarcopenia/severe sarcopenia throughout the 5 years of follow-up was evaluated using the Cox proportional hazards model. Results: In total, the study population included 420 participants, with a median age of 71.7 years (P25 eP75 ¼ 67.7e76.9 years) and 59.8% were female. Over the 5 years of follow-up, 78 participants (18.6%) became sarcopenic as per the EWGSOP2 criteria and 41 individuals (9.8%) developed severe sarcopenia. There were significantly more smokers than non-smokers who developed sarcopenia (35.9% vs 16.8%, Pvalue ¼ 0.003). A fully adjusted Cox model confirmed this observation, yielding a hazard ratio of 2.36 (95% confidence interval [CI]: 1.31e4.26), meaning that smokers have a 2.36-fold higher risk of developing sarcopenia. Furthermore, individuals who smoked had a 2.68 times increased risk of developing severe sarcopenia (95% CI: 1.21e5.93) than those who did not smoke. Sensitivity analyses globally confirmed these findings when applying other diagnostic criteria for sarcopenia. Discussion: Smoking seems to be an important predictor for the onset of sarcopenia, highlighting, once again, that tobacco use is a major public health problem.

Disciplines :

Public health, health care sciences & services

Author, co-author :

Locquet, Médéa ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie clinique

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Lengele, Laetitia ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Beaudart, Charlotte ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Language :

English

Title :

Relationship between smoking and the incidence of sarcopenia: The SarcoPhAge cohort

Publication date :

2021

Journal title :

Public Health

ISSN :

0033-3506

eISSN :

1476-5616

Publisher :

Elsevier

Volume :

193

Pages :

101-108

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 May 2021

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Bibliography

Cruz-Jentoft, A.J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., et al. Sarcopenia: revised European consensus on definition and diagnosis. [cited 2018 Oct 21] Age Ageing [Internet] 48(1) (2018 Oct 12), 16–31 Available from: https://academic.oup.com/ageing/advance-article/doi/10.1093/ageing/afy169/5126243.
Bruyère, O., Beaudart, C., Locquet, M., Buckinx, F., Petermans, J., Reginster, J.-Y., Sarcopenia as a public health problem. [cited 2019 Jun 17] Eur Geriatr Med [Internet] 7:3 (2016 Jun 1), 272–275 Available from: https://www.sciencedirect.com/science/article/pii/S1878764915002363.
Shafiee, G., Keshtkar, A., Soltani, A., Ahadi, Z., Larijani, B., Heshmat, R., Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies. [cited 2017 Jul 14] J Diabetes Metab Disord [Internet], 16(1), 2017 Dec 16, 21 Available from: http://www.ncbi.nlm.nih.gov/pubmed/28523252.
Ethgen, O., Beaudart, C., Buckinx, F., Bruyère, O., Reginster, J.Y., The future prevalence of sarcopenia in Europe: a claim for public health action. [cited 2017 Feb 27] Calcif Tissue Int [Internet] 100:3 (2017 Mar 24), 229–234 Available from: http://link.springer.com/10.1007/s00223-016-0220-9.
Bruyère, O., Beaudart, C., Ethgen, O., Reginster, J.Y., Locquet, M., The health economics burden of sarcopenia: a systematic review, vol. 119, 2019, Maturitas. Elsevier Ireland Ltd, 61–69.
Locquet, M., Beaudart, C., Petermans, J., Reginster, J.-Y., Bruyère, O., EWGSOP2 versus EWGSOP1: impact on the prevalence of sarcopenia and its major health consequences. J Am Med Dir Assoc 20:3 (2019 Mar), 384–385.
Atmis, V., Yalcin, A., Silay, K., Ulutas, S., Bahsi, R., Turgut, T., et al. The relationship between all-cause mortality sarcopenia and sarcopenic obesity among hospitalized older people. [cited 2020 Oct 9] Aging Clin Exp Res [Internet] 31:11 (2019 Nov 1), 1563–1572 Available from: https://pubmed.ncbi.nlm.nih.gov/31350700/.
Yang, M., Liu, Y., Zuo, Y., Tang, H., Sarcopenia for predicting falls and hospitalization in community-dwelling older adults: EWGSOP versus EWGSOP2. [cited 2020 Aug 29] Sci Rep [Internet], 9(1), 2019 Dec 1 Available from: https://pubmed.ncbi.nlm.nih.gov/31776354/.
Vaes, B., Pasquet, A., Wallemacq, P., Rezzoug, N., Mekouar, H., Olivier, P.-A., et al. The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium. [cited 2018 Jun 12] BMC Geriatr [Internet], 10(1), 2010 Dec 17, 39 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20565795.
Beaudart, C., Reginster, J.Y., Petermans, J., Gillain, S., Quabron, A., Locquet, M., et al. Quality of life and physical components linked to sarcopenia: the SarcoPhAge study. [cited 2018 Oct 2] Exp Gerontol [Internet] 69 (2015 Sep), 103–110 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25979160.
Wong, R., Ofstedal, M.B., Yount, K., Agree, E.M., Unhealthy lifestyles among older adults: exploring transitions in Mexico and the US. [cited 2020 Oct 8] Eur J Ageing [Internet] 5:4 (2008), 311–326 Available from: articles/PMC4239542/?report=abstract.
Beaudart, C., Sanchez-Rodriguez, D., Locquet, M., Reginster, J.Y., Lengelé, L., Bruyère, O., Malnutrition as a strong predictor of the onset of sarcopenia. [cited 2020 Aug 29] Nutrients [Internet], 11(12), 2019 Dec 1 Available from: https://pubmed.ncbi.nlm.nih.gov/31783482/.
Sieber, C.C., Malnutrition and sarcopenia. Aging clinical and experimental research. 2019, Springer International Publishing.
Meier, N.F., Lee, D., chul. Physical activity and sarcopenia in older adults. [cited 2020 Oct 9] Aging Clin Exp Res [Internet] 32:9 (2020 Sep 1), 1675–1687 Available from: https://pubmed.ncbi.nlm.nih.gov/31625078/.
Bonnie, R.J., Stratton, K., Kwan, L.Y., Products C on the PHI of R the MA for PT, practice B on PH and PH, medicine I of. The effects of tobacco use on health. [cited 2020 Oct 8], 2015 Jul 23 Available from: https://www.ncbi.nlm.nih.gov/books/NBK310413/.
Samet, J.M., Epidemiology and the tobacco epidemic: how research on tobacco and health shaped Epidemiology. [cited 2021 Jan 6] Am J Epidemiol [Internet] 183:5 (2016 Mar 1), 394–402 Available from: https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwv156.
Steffl, M., Bohannon, R.W., Petr, M., Kohlikova, E., Holmerova, I., Kohlíková, E., Relation between cigarette smoking and sarcopenia: meta-analysis. [cited 2020 Aug 29] Physiol Res [Internet] 64 (2015), 419–426 Available from: www.biomed.cas.cz/physiolres.
Locquet, M., Beaudart, C., Hajaoui, M., Petermans, J., Reginster, J.-Y., Bruyère, O., Three-year adverse health consequences of sarcopenia in community-dwelling older adults according to 5 diagnosis definitions. [cited 2018 Sep 13] J Am Med Dir Assoc [Internet] 20(1) (2018 Jul 19), 43–46 Available from: http://www.ncbi.nlm.nih.gov/pubmed/30032996.
Von Elm, E., Altman, D.G., Egger, M., Pocock, S.J., Gøtzsche, P.C., Vandenbroucke, J.P., The strengthening the reporting of observational studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med 4:10 (2007 Oct), 1623–1627.
Beaudart, C., Reginster, J.Y., Petermans, J., Gillain, S., Quabron, A., Locquet, M., et al. Quality of life and physical components linked to sarcopenia: the SarcoPhAge study. Exp Gerontol, 69, 2015.
NHIS - adult tobacco use - glossary [Internet]. [cited 2021 Jan 6]; Available from: https://www.cdc.gov/nchs/nhis/tobacco/tobacco_glossary.htm.
Roberts, H.C., Denison, H.J., Martin, H.J., Patel, H.P., Syddall, H., Cooper, C., et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. [cited 2017 Feb 28] Age Ageing [Internet] 40:4 (2011 Jul 1), 423–429 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21624928.
Guralnik, J.M., Ferrucci, L., Pieper, C.F., Leveille, S.G., Markides, K.S., Ostir, G.V., et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. [cited 2017 Feb 26] J Gerontol A Biol Sci Med Sci [Internet] 55:4 (2000 Apr), M221–M231 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10811152.
Cruz-Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boirie, Y., Cederholm, T., Landi, F., et al. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. [cited 2017 Feb 21] Age Ageing [Internet] 39:4 (2010 Jul), 412–423 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20392703.
Fielding, R.A., Vellas, B., Evans, W.J., Bhasin, S., Morley, J.E., Newman, A.B., et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. [cited 2017 Feb 21] J Am Med Dir Assoc [Internet] 12:4 (2011 May), 249–256 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21527165.
Morley, J.E., Abbatecola, A.M., Argiles, J.M., Baracos, V., Bauer, J., Bhasin, S., et al. Sarcopenia with limited mobility: an international consensus. [cited 2017 Feb 21] J Am Med Dir Assoc [Internet] 12:6 (2011 Jul), 403–409 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21640657.
Studenski, S.A., Peters, K.W., Alley, D.E., Cawthon, P.M., McLean, R.R., Harris, T.B., et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. [cited 2017 Feb 21] J Gerontol Ser A Biol Sci Med Sci [Internet] 69:5 (2014 May 1), 547–558 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24737557.
Tombaugh, T.N., McIntyre, N.J., The mini-mental state examination: a comprehensive review. [cited 2019 Sep 24] J Am Geriatr Soc [Internet] 40:9 (1992 Sep 1), 922–935, 10.1111/j.1532-5415.1992.tb01992.x Available from:.
Elosua, R., Marrugat, J., Molina, L., Pons, S., Pujol, E., Validation of the Minnesota leisure time physical activity questionnaire in Spanish men. [cited 2018 Jul 17] Am J Epidemiol [Internet] 139:12 (1994 Jun 15), 1197–1209 Available from: https://academic.oup.com/aje/article/141115/Validation.
Cereda, E., Mini nutritional assessment. [cited 2019 Sep 24] Curr Opin Clin Nutr Metab Care [Internet] 15:1 (2012 Jan), 29–41 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22037014.
Hill, A., The environment and disease: association or causation?. [cited 2019 Oct 15] Proc Roy Soc Med [Internet] 58:5 (1965 May), 295–300 Available from: http://www.ncbi.nlm.nih.gov/pubmed/14283879.
Rom, O., Kaisari, S., Aizenbud, D., Reznick, A.Z., Sarcopenia and smoking: a possible cellular model of cigarette smoke effects on muscle protein breakdown. [cited 2020 Aug 29] Ann N Y Acad Sci [Internet] 1259:1 (2012 Jul 1), 47–53, 10.1111/j.1749-6632.2012.06532.x Available from:.
Nogueira, L., Trisko, B.M., Lima-Rosa, F.L., Jackson, J., Lund-Palau, H., Yamaguchi, M., et al. Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice. [cited 2020 Oct 9] J Physiol [Internet] 596:14 (2018 Jul 15), 2901–2916 Available from: https://pubmed.ncbi.nlm.nih.gov/29797443/.
Jo, Y., Linton, J.A., Choi, J., Moon, J., Kim, J., Lee, J., et al. Association between cigarette smoking and sarcopenia according to obesity in the middle-aged and elderly Korean population: the Korea national health and nutrition examination survey (2008-2011). [cited 2020 Aug 29] Korean J Fam Med [Internet] 40:2 (2019), 87–92 Available from: https://pmc/articles/PMC6444086/?report=abstract.
Akune, T., Muraki, S., Oka, H., Tanaka, S., Kawaguchi, H., Nakamura, K., et al. Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. [cited 2020 Aug 29] Osteoporos Int [Internet] 25:3 (2014 Mar), 1081–1088 Available from: https://pubmed.ncbi.nlm.nih.gov/24146097/.