Article (Scientific journals)
Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer
Brohée, Laura; Cremer, Julie; Colige, Alain et al.
2021In International Journal of Molecular Sciences, 22 (9), p. 4419
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Keywords :
Lipin-1; cancer; metabolism; lipids; propranolol; fatty acids; phosphatidic acid phosphatase
Abstract :
[en] The rewiring of lipid metabolism is a major adaptation observed in cancer, and it is generally associated with the increased aggressiveness of cancer cells. Targeting lipid metabolism is therefore an appealing therapeutic strategy, but it requires a better understanding of the specific roles played by the main enzymes involved in lipid biosynthesis. Lipin-1 is a central regulator of lipid homeostasis, acting either as an enzyme or as a co-regulator of transcription. In spite of its important functions it is only recently that several groups have highlighted its role in cancer. Here, we will review the most recent research describing the role of lipin-1 in tumor progression when expressed by cancer cells or cells of the tumor microenvironment. The interest of its inhibition as an adjuvant therapy to amplify the effects of anti-cancer therapies will be also illustrated.
Research center :
Giga-Cancer - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Oncology
Author, co-author :
Brohée, Laura;  Max Planck Institute for Biology of Ageing (MPI-AGE), 50931 Cologne, Germany.
Cremer, Julie ;  Université de Liège - ULiège > GIGA Cancer - Connective Tissue Biology
Colige, Alain ;  Université de Liège - ULiège > GIGA Cancer - Connective Tissue Biology
Deroanne, Christophe ;  Université de Liège - ULiège > GIGA Cancer - Connective Tissue Biology
Language :
English
Title :
Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer
Publication date :
23 April 2021
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Special issue title :
The Interplay between Metabolism and Cancer and the Adipose Tissue Communication Signals
Volume :
22
Issue :
9
Pages :
4419
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 May 2021

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