[en] Ten outpatients with panic disorder were treated over an 8 week-period with milnacipran, an antidepressant active on both noradrenergic and serotonergic systems, at a dose between 100 and 150 mg/d. Clinical assessments included the Hamilton Anxiety Scale and the Cottraux Rating Scale for phobias, panic attacks, and generalized anxiety. Results showed very significant improvements in the frequency and intensity of panic attacks, and in the level of generalized anxiety. A good or excellent response was noted in 7 patients. Only 3 patients complained of side-effects, mostly of the digestive type. These promising results of milnacipran in panic disorder need to be confirmed in controlled studies.
