Article (Scientific journals)
The Effects of In-Plane Spatial Resolution on CT-Based Radiomic Features' Stability with and without ComBat Harmonization.
Ibrahim, Abdalla; Refaee, Turkey; Primakov, Sergey et al.
2021In Cancers, 13 (8)
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Keywords :
harmonization; image processing; radiomics biomarkers; reproducibility
Abstract :
[en] While handcrafted radiomic features (HRFs) have shown promise in the field of personalized medicine, many hurdles hinder its incorporation into clinical practice, including but not limited to their sensitivity to differences in acquisition and reconstruction parameters. In this study, we evaluated the effects of differences in in-plane spatial resolution (IPR) on HRFs, using a phantom dataset (n = 14) acquired on two scanner models. Furthermore, we assessed the effects of interpolation methods (IMs), the choice of a new unified in-plane resolution (NUIR), and ComBat harmonization on the reproducibility of HRFs. The reproducibility of HRFs was significantly affected by variations in IPR, with pairwise concordant HRFs, as measured by the concordance correlation coefficient (CCC), ranging from 42% to 95%. The number of concordant HRFs (CCC > 0.9) after resampling varied depending on (i) the scanner model, (ii) the IM, and (iii) the NUIR. The number of concordant HRFs after ComBat harmonization depended on the variations between the batches harmonized. The majority of IMs resulted in a higher number of concordant HRFs compared to ComBat harmonization, and the combination of IMs and ComBat harmonization did not yield a significant benefit. Our developed framework can be used to assess the reproducibility and harmonizability of RFs.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Ibrahim, Abdalla
Refaee, Turkey
Primakov, Sergey
Barufaldi, Bruno
Acciavatti, Raymond J.
Granzier, Renée W. Y.
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Mottaghy, Felix M.
Woodruff, Henry C.
Wildberger, Joachim E.
Lambin, Philippe
Maidment, Andrew D. A.
Language :
English
Title :
The Effects of In-Plane Spatial Resolution on CT-Based Radiomic Features' Stability with and without ComBat Harmonization.
Publication date :
2021
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
13
Issue :
8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 May 2021

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