Article (Scientific journals)
The faecal abundance of short chain fatty acids is increased in men with a non-dipping blood pressure profile
HUART, Justine; Cirillo, Arianna; SAINT-REMY, Annie et al.
2021In Acta Cardiologica
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Keywords :
Hypertension; Gut microbiota; Dipping; Short chain fatty acid; Non-dipping blood pressure profile; Metabolomics
Abstract :
[en] Background and aims: Gut microbiota (GM) has been involved in the pathophysiology of hypertension (HT), notably via short chain fatty acids (SCFAs). Among the clinical manifestations of HT, the absence of a significant drop in night-time blood pressure (BP) (also known as the non-dipping BP profile) has been associated with poor renal and cardiovascular outcomes. The putative link between GM-derived metabolites and BP dipping status is still unknown. Methods: Male volunteers (n ¼ 44) were prospectively subjected to 24-hour ambulatory blood pressure monitoring, stool sample collection and a medical questionnaire. Metabolomics analy ses of stool samples were conducted using Nuclear Magnetic Resonance (NMR). Results: Higher amounts of acetate, butyrate and propionate were found in the stools of non dippers (n ¼ 12) versus dippers (n ¼ 26) (p ¼ 0.0252, p ¼ 0.0468, and p ¼ 0.0496, respectively; n ¼ 38 in toto). NMR spectral data were not interpretable in 5 dippers and 1 non-dipper. A simi lar significant association was found when including only patients without anti-HT medications (p ¼ 0.0414, p ¼ 0.0108, and p ¼ 0.0602, respectively; n ¼ 21 in toto). A not significant trend was observed when focussing only on HT patients without anti-HT medications (p ¼ 0.0556; n ¼ 14 in toto). Conclusion: Our pilot study highlights a putative link between GM-derived SCFAs and the BP dipping status, independently of the BP status itself or the anti-hypertensive medications.
Disciplines :
Laboratory medicine & medical technology
Urology & nephrology
Author, co-author :
HUART, Justine   ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Cirillo, Arianna  ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
SAINT-REMY, Annie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
KRZESINSKI, Jean-Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
De Tullio, Pascal  ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Jouret, François   ;  Université de Liège - ULiège > GIGA Cardio. Sc. - Lab. of Translational Res. in Nephrology
 These authors have contributed equally to this work.
Language :
English
Title :
The faecal abundance of short chain fatty acids is increased in men with a non-dipping blood pressure profile
Publication date :
31 March 2021
Journal title :
Acta Cardiologica
ISSN :
0001-5385
eISSN :
1784-973X
Publisher :
Association Royale des Sociétés Scientifiques Medicales Belges/Koninklijke Vereniging van de Belgische Medische Wetenschappelijke Genootschappen, Bruxelles, Belgium
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 May 2021

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