Article (Scientific journals)
Dopamine-glutamate reciprocal modulation of release and motor responses in the rat caudate-putamen and nucleus accumbens of "intact" animals
David, H. N.; Ansseau, Marc; Abraini, J. H.
2005In Brain Research Reviews, 50 (2), p. 336-360
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Keywords :
striatum; nucleus accumbens; D1-like receptor; D2-like receptor; glutamatergic ionotropic receptor; glutamatergic metabotropic receptor; functional interactions; locomotor activity; neurochemistry
Abstract :
[en] Functional interactions between dopaminergic neurotransmission and glutamatergic neurotransmission are well known to play a crucial integrative role in the striatum, the major input structure of the basal ganglia now widely recognized to contribute to the control of motor activity and movements but also to the processing of cognitive and limbic functions. However, the nature of these interactions is still a matter of debate and controversy. This review (1) summarizes anatomical data on the distribution of dopaminergic and glutamatergic receptors in the striatum-accumbens complex, (2) focuses on the dopamine-glutamate interactions in the modulation of each other's release in the striatum-accumbens complex, and (3) examines the dopamine-glutamate interactions in the entire striatum involved in the control of locomotor activity. The effects of dopaminergic and glutamatergic receptor selective agonists and antagonists on dopamine and glutamate release as well on motor responses are analyzed in the entire striatum, by reviewing both in vitro and in vivo data. Regarding in vivo data, only findings from focal injections studies in the nucleus accumbens or the caudate-putamen of "intact" animals are reviewed. Altogether, the available data demonstrate that dopamine and glutamate do not uniformly interact to modulate each others' release and postsynaptic modulation of striatal output neurons. Depending on the receptor subtypes involved, interactions between dopaminergic and glutamatergic transmission vary as a multiple and complex combination of tonic, phasic, facilitatory, and inhibitory properties. (c) 2005 Elsevier B.V. All rights reserved.
Disciplines :
Neurosciences & behavior
Author, co-author :
David, H. N.
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Abraini, J. H.
Language :
English
Title :
Dopamine-glutamate reciprocal modulation of release and motor responses in the rat caudate-putamen and nucleus accumbens of "intact" animals
Publication date :
15 December 2005
Journal title :
Brain Research Reviews
ISSN :
0165-0173
eISSN :
1872-6321
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
50
Issue :
2
Pages :
336-360
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 April 2021

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