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ADAM28: Another ambivalent protease in cancer
Hubeau, Céline; Rocks, Natacha; Cataldo, Didier
2020In Cancer Letters, 494, p. 18-26
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Keywords :
ADAM28; Cancer biomarker; Cell proliferation; Metastasis; Tumor microenvironment
Abstract :
[en] Emergence of novel therapeutic options in a perspective of personalized therapy of cancer relies on the discovery of precise molecular mechanisms involved in the switch from a localized tumor to invasive metastasis spread. Pro-tumor functions have been mostly ascribed to proteolytic enzymes from the metalloproteinase family including A Disintegrin And Metalloproteinases (ADAMs). Particularly, when expressed by cancer cells, ADAM28 protease supports cancer cell proliferation, survival and migration as well as metastatic progression. In sharp contrast, ADAM28 derived from the tumor microenvironment has shown to exert strong protective effects against deleterious metastasis dissemination. Indeed, depletion of host-derived ADAM28 (ADAM28 KO mice) accelerates colonization lung tissues, increases tumor foci implantation, and impairs T cell immune response. In this review, we outline specific ADAM28 functions when specifically expressed by carcinoma cells or by tumor microenvironment. Finally, we discuss about future research strategies that could be pursued to highlight new functions of this protease in cancer. © 2020 Elsevier B.V.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Hubeau, Céline ;  Université de Liège - ULiège > GIGA
Rocks, Natacha ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Cataldo, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Language :
English
Title :
ADAM28: Another ambivalent protease in cancer
Publication date :
2020
Journal title :
Cancer Letters
ISSN :
0304-3835
eISSN :
1872-7980
Publisher :
Elsevier Ireland Ltd
Volume :
494
Pages :
18-26
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 April 2021

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