Article (Scientific journals)
Apomorphine Stimulation of Vasopressin- and Oxytocin-Neurophysins. Evidence for Increased Oxytocinergic and Decreased Vasopressinergic Function in Schizophrenics
Legros, Jean-Jacques; Gazzotti, C.; Carvelli, Thierry et al.
1992In Psychoneuroendocrinology, 17 (6), p. 611-617
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Keywords :
Schizophrenia; Oxytocin; Dopamine; Apomorphine
Abstract :
[en] Apomorphine challenge tests (0.5 mg SC) were performed in 14 normal male volunteers and in 9 male schizophrenic inpatients, drug-free for at least 2 wk. In the normal volunteers, apomorphine induced an increase of serum growth hormone (GH) (maximum at 40 min), of vasopressin-neurophysin (hNpI) (maximum at 20 min), and oxytocin-neurophysin (hNpII) (maximum at 20 min). The release of neurophysins was independent of digestive side effects. In the schizophrenics, the GH level and release pattern were similar to those in the controls. The basal level of hNpI was reduced (t0: 0.42 +/- 0.1 ng/ml in the schizophrenics and 0.66 +/- 0.05 ng/ml in the controls, p < 0.02). In contrast, the basal level of hNpII was increased (3.34 +/- 0.04 ng/ml in the schizophrenics to 0.92 +/- 0.21 ng/ml in the controls, p = 0.001). The response to apomorphine was blunted, with no significant release of hNpI or of hNpII. Although the hNpII data are consistent with an increased dopaminergic tone, the psychopathological meaning of the increased basal oxytocinergic and decreased vasopressinergic functions remains to be defined.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Legros, Jean-Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Gazzotti, C.
Carvelli, Thierry;  Centre Hospitalier Universitaire de Liège - CHU
Franchimont, Paul
Timsit-Berthier, M.
von Frenckell, Rémy 
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Language :
English
Title :
Apomorphine Stimulation of Vasopressin- and Oxytocin-Neurophysins. Evidence for Increased Oxytocinergic and Decreased Vasopressinergic Function in Schizophrenics
Publication date :
1992
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Elsevier, United Kingdom
Volume :
17
Issue :
6
Pages :
611-617
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 April 2021

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