Article (Scientific journals)
Relation entre le test de suppression à la dexaméthasone et la variation contingente négative chez des patients déprimés majeurs
Mantanus, H.; Ansseau, Marc; Legros, Jean-Jacques et al.
1988In Neurophysiologie Clinique, 18 (4), p. 345-353
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Keywords :
Depression; Contingent Negative Variation; Dexamethasone Suppression Test
Abstract :
[en] We tried to relate two different indexes sensitive to the perturbations induced by major depression: the Dexamethasone Suppression Test or DST (Caroll, 1982) and the Contingent Negative Variation (CNV). The question was whether abnormalities in cortisol levels, following dexamethasone would enlight the modifications observed in CNV parameters and other electrophysiological indexes (EEG spectrum, reaction time). In 61 major depressive patients, 29 being DST-non-suppressors, we calculated differences in electrophysiological variables according to DST suppression or not, but we were not able to evidence significant differences between the groups. However, there were correlations between log-transformed levels of cortisol and on the one hand, CNV slope (r = -0.34, P less than 0.03) and on the other hand, reaction time (r = 0.45, P less than 0.01). Correlations between electrophysiological variables appeared in the sole suppressors group (e.g. CNV amplitude and alpha rythm reactivity; post-imperative variation and percent beta of the EEG spectrum). These results underline the complementary aspect of the two methods.
Disciplines :
Neurosciences & behavior
Author, co-author :
Mantanus, H.
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Legros, Jean-Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Timsit-Berthier, M. 
Language :
French
Title :
Relation entre le test de suppression à la dexaméthasone et la variation contingente négative chez des patients déprimés majeurs
Alternative titles :
[en] Relationship between Dexamethasone Suppression Test and Contingent Negative Variation in Major Depressive Patients
Publication date :
1988
Journal title :
Neurophysiologie Clinique
ISSN :
0987-7053
eISSN :
1769-7131
Publisher :
Elsevier, United States - New York
Volume :
18
Issue :
4
Pages :
345-353
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 April 2021

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