Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non- pregnant rats.

[en] In the present study we report that the effects of sertraline treat on the hippocampus of pregnant and non-pregnant females differs as a function of reproductive state as well as dose. We found that although serum drug levels were elevated in late pregnant females the rates of serotonin turnover in the hippocampus and PFC were similar in pregnant and non-pregnant females. However, we found that sertraline increased synaptophysin density and was associated with decreased cell proliferation rates in the hippocampus of non-pregnant females only. Pregnancy alone resulted in significant reductions in hippocampal neurogenesis and increased synaptophysin density, regardless of sertraline treatment. In conclusion, this work highlights the need to consider how reproductive state affects the central actions of antidepressant medication treatment for peripartum mood and anxiety disorders.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Pawluski, Jodi L.

Paravatou, Rafaella

Even, Alan

COBRAIVILLE, Gaël ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Kobras, Nikolaos

Dalla, Christina

Charlier, Thierry D.

Language :

English

Title :

Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non- pregnant rats.

Publication date :

2020

Journal title :

Neuropharmacology

ISSN :

0028-3908

eISSN :

1873-7064

Publisher :

Elsevier, Oxford, United Kingdom

Volume :

166

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 April 2021

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