Applications de l'extraction et du dosage radioimmunologique du LH-RH dans les urines humaines

The existence of endogenous LH-RH like immunoreactivity is shown in human urines after appropriate extraction, by the radioimmunoassay of LH-RH. In normally cycling and menopausal women the quantities of endogenous hormone found in urines are greater after acid extraction than those found after extraction at pH 7. Furthermore, the increase observed by extraction in acidified methanol is directly correlated and proportional to the quantity of hormone assayable by extraction at pH 7. The hypothesis of urinary excretion of LH-RH as a polymer of immunoreactive units is suggested by this study.