Article (Scientific journals)
Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate.
Liu, Xiaojin; Eickhoff, Simon B.; Caspers, Svenja et al.
2021In NeuroImage, p. 118006
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Keywords :
Parkinson's disease; Schizophrenia; connectivity-based parcellation; cross-species comparison; non-human primate; striatum
Abstract :
[en] A wide homology between human and macaque striatum is often assumed as in both the striatum is involved in cognition, emotion and executive functions. However, differences in functional and structural organization between human and macaque striatum may reveal evolutionary divergence and shed light on human vulnerability to neuropsychiatric diseases. For instance, dopaminergic dysfunction of the human striatum is considered to be a pathophysiological underpinning of different disorders, such as Parkinson's disease (PD) and schizophrenia (SCZ). Previous investigations have found a wide similarity in structural connectivity of the striatum between human and macaque, leaving the cross-species comparison of its functional organization unknown. In this study, resting-state functional connectivity (RSFC) derived striatal parcels were compared based on their homologous cortico-striatal connectivity. The goal here was to identify striatal parcels whose connectivity is human-specific compared to macaque parcels. Functional parcellation revealed that the human striatum was split into dorsal, dorsomedial, and rostral caudate and ventral, central, and caudal putamen, while the macaque striatum was divided into dorsal, and rostral caudate and rostral, and caudal putamen. Cross-species comparison indicated dissimilar cortico-striatal RSFC of the topographically similar dorsal caudate. We probed clinical relevance of the striatal clusters by examining differences in their cortico-striatal RSFC and gray matter (GM) volume between patients (with PD and SCZ) and healthy controls. We found abnormal RSFC not only between dorsal caudate, but also between rostral caudate, ventral, central and caudal putamen and widespread cortical regions for both PD and SCZ patients. Also, we observed significant structural atrophy in rostral caudate, ventral and central putamen for both PD and SCZ while atrophy in the dorsal caudate was specific to PD. Taken together, our cross-species comparative results revealed shared and human-specific RSFC of different striatal clusters reinforcing the complex organization and function of the striatum. In addition, we provided a testable hypothesis that abnormalities in a region with human-specific connectivity, i.e., dorsal caudate, might be associated with neuropsychiatric disorders.
Disciplines :
Neurosciences & behavior
Author, co-author :
Liu, Xiaojin
Eickhoff, Simon B.
Caspers, Svenja
Wu, Jianxiao
Genon, Sarah ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.
Hoffstaedter, Felix
Mars, Rogier B.
Sommer, Iris E.
Eickhoff, Claudia R.
Chen, Ji
Jardri, Renaud
Reetz, Kathrin
Dogan, Imis
Aleman, André
Kogler, Lydia
Gruber, Oliver
Caspers, Julian
Mathys, Christian
Patil, Kaustubh R.
More authors (9 more) Less
Language :
English
Title :
Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate.
Publication date :
2021
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Elsevier, Amsterdam, Netherlands
Pages :
118006
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021. Published by Elsevier Inc.
Available on ORBi :
since 12 April 2021

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