[en] The curcumin degradation represents a significant limitation for its applications. The stability of free curcumin (FC) and immobilized curcumin in complex particles (ComPs) based on different polysaccharides was studied under the action of several factors. Ultraviolet-visible (UV-VIS) and Fourier-transform infrared (FTIR) spectroscopy proved the FC photodegradation and its role as a metal chelator: 82% of FC and between 26% and 39.79% of curcumin within the ComPs degraded after exposure for 28 days to natural light. The degradation half-life (t1/2) decreases for FC when the pH increases, from 6.8 h at pH = 3 to 2.1 h at pH = 9. For curcumin extracted from ComPs, t1/2 was constant (between 10 and 13 h) and depended on the sample’s composition. The total phenol (TPC) and total flavonoids (TFC) content values increased by 16% and 13%, respectively, for FC exposed to ultraviolet light at λ = 365 nm (UVA), whereas no significant change was observed for immobilized curcumin. Antioxidant activity expressed by IC50 (µmoles/mL) for FC exposed to UVA decreased by 29%, but curcumin within ComPs was not affected by the UVA. The bovine serum albumin (BSA) adsorption efficiency on the ComPs surface depends on the pH value and the cross-linking degree. ComPs have a protective role for the immobilized curcumin.
Research center :
Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Iurciuc-Tincu, Camelia-Elena; Grigore T. Popa University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, Faculty, Iasi, Romania > Gheorghe Asachi Technical University, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Iasi, Romania
Atanase, Leonard Ionut; Apollonia University, Faculty of Dental Medicine, Department of Biomaterials, Iasi, Romania
Jérôme, Christine ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Sol, Vincent; University of Limoges, Laboratoire PEIRENE EA 7500, France
Martin, Patrick; Université d’Artois,Unité Transformations & Agroressources, UniLaSalle, Béthune, France
Popa, Marcel; Gheorghe Asachi Technical University, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Iasi, Romania > Academy of Romanian Scientists, Bucharest, Romania
Ochiuz, Lăcrămioara; Grigore T. Popa University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, Faculty, Iasi, Romania
Language :
English
Title :
Polysaccharides-based complex particles’ protective role on the stability and bioactivity of immobilized curcumin
Publication date :
17 March 2021
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
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