Schizophrenia; Animal model; High pressure; Dopamine; Amino acids
Abstract :
[en] Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.
Disciplines :
Neurosciences & behavior
Author, co-author :
Abraini, Jacques H.
Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Fechtali, T.
Language :
English
Title :
Pressure-Induced Disorders in Neurotransmission and Spontaneous Behavior in Rats: An Animal Model of Psychosis
Abraini, Fechtali (1992) A hypothesis regarding possible interactions between the pressure-induced disorders in dopaminergic and amino-acidergic transmission. Neurosci Biobehav Rev 16:597-602.
Abraini, Rostain (1991) Pressure-induced dopamine release correlates locomotor activity in rats exposed to high pressure. J Appl Physiol 71:638-643.
Abraini, Rostain (1991) Dopamine increase in the nucleus accumbens of rats exposed to high pressure. Neuroreport 2:233-235.
Abraini, Rostain (1991) Effects of the administration of a-methyl-p-tyrosine on the striatal dopamine increase and the behavioral motor disturbances in rats exposed to high pressure. Pharmacol Biochem Behav 40:305-310.
Abraini, Tomei, Rostain (1991) Role of dopamine receptors in the occurrence of the behavioral motor disturbances in rats exposed to high pressure. Pharmacol Biochem Behav 39:773-777.
Abraini, Fechtali, Rostain (1992) Pressure reverses extracellular striatal dopamine decrease produced by D1 receptor agonist SKF 38393, and D2 receptor agonist LY 171555, but failed to change the effect of the activation of both D1 and D2 receptors. Neuroscience 50:395-402.
Bennett, Leventhal, Goggin (1980) Lithium effects: protection against nitrogen narcosis, potentiation of HPNS. Undersea Biomed Res 7:11-16.
Bowers (1974) Central dopamine in schizophrenic syndromes. Arch Gen Psychiatry 31:50-54.
Brauer, Mansfield, Beaver, Gillen (1981) The HPNS as composite entity—consequences of an analysis of the convulsion stage. Underwater Physiology VII , A.J. Bachrach, M.M. Matzen, Undersea Medical Society, Bethesda, MD; 391-399.
Creese, Burt, Snyder (1976) Dopamine receptor binding predicts clinical and pharmacological potences of antischizophrenic drugs. Science 192:481-483.
Davidson, Davis (1988) A comparison of plasma homovanilic acid concentrations in schizophrenic patients and normal controls. Arch Gen Psychiatry 45:561-563.
Davis, Davidson, Mohs (1985) Plasma homovanilic acid concentration and the severity of schizophrenic illness. Science 227:1601-1602.
Davis, Kahn, Ko, Davidson (1991) Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 148:1474-1486.
Delisi, Goldin, Gershon (1987) Studies of biological factors associated with the inheritance of schizophrenia: a selective review. J Psychiatry Res 21:507-513.
Douchet, Raoul, Trividic (1990) Psycho-activité de l'hydrogène en pression. Plongée Humaine en Mélange Hydrogène-Oxygène dite Hydra IX, DRET report n°89-1305, C.E.R.B, Toulon-naval; .
El Ganouni, Forni, Nieoullon (1987) In vitro and in vivo characterization of the properties of a multifiber carbon electrode allowing long-term electrochemical detection of dopamine in freely-moving animals. Brain Res 404:239-256.
Ellenbroek, Cools (1991) Animal models for schizophrenia. Bioloical Psychiatry , G. Racagni, N. Brunello, T. Fukuda, Excerta Medica, Amsterdam; 2:605-607.
Fagni, Zinebi, Hugon (1987) Helium pressure potentiates the N-methyl-D-aspartate and D,L-homocysteate-induced decreases of field potentials in the rat hippocampal slices preparation. Neurosci Lett 81:285-290.
Faux, Shenton, MacCarley (1990) Preservation of P300 event-related potential topographic asymmetries in schizophrenia with use of either linke-ear or nose reference sites. Electroenceph Clin Neurophysiol 75:378-391.
Goldin, Delisi, Gershon (1987) Unravelling the relation between genetic and environmental risk factors in psychiatric disorders. Br J Psychiatry 151:302-305.
Grace (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia. Neuroscience 41:1-24.
Halsey (1982) Effects of high pressure on the central nervous system. Physiol Rev 62:1341-1377.
Halsey, Wardley-Smith (1975) Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquilizers. Nature 257:811.
Itil (1977) Qualitative and quantitative EEG findings in schizophrenics. Schizophr Bull 3:61-79.
Kim, Kornhuber, Schmid-Burgk, Holzmuller (1980) Low cerebral spinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20:379-382.
Kornhuber, Mack-Burkhardt, Riederer (1989) 3H-MK801 binding sites in post-mortem brain regions of schizophrenic patients. Journal of Neural Transmission 77:3231-3236.
Lemaire, Rostain The High Pressure Nervous Syndrome, Octares Publications, Marseilles; 1988.
Maas, Contreras, Seleshi (1988) Dopamine metabolism and disposition in schizophrenic patients. Arch Gen Psychiatry 45:553-559.
MacLeod, Bennett, Cooper (1988) Rat brain catecholamine release at 1, 10, 20 and 100, ATA heliox, nitrox, and trimix. Undersea Biomed Res 15:211-221.
Matthysse (1973) Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?. Fed Proceed 32:200.
Meldrum, Wardley-Smith, Halsey, Rostain (1983) 2-amino-7-phosphonoheptanoic acid protects against the high pressure neurological syndrome. Eur J Pharmacol 87:501-502.
Meltzer (1987) Biological studies in schizophrenia. Schizophr Bull 13:77-97.
Millan, Wardley-Smith, Halsey, Meldrum (1989) Studies on the role of NMDA receptor in the substancia nigra pars retuculata and entopenduncular nucleus in development of the high pressure neurological syndrome in rats. Exp Brain Res 78:174-178.
Millan, Wardley-Smith, Halsey, Meldrum (1990) Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat. Brain Res 507:354-356.
Muller, Seeman (1978) Dopaminergic supersensitivity after neuroleptics: time-course and specificity. Psychopharmacology 60:1-11.
Paul, Philp (1989) Hyperbaric He but not N2 augments Ca2+-dependent dopamine release from rat striatum. Undersea Biomed Res 16:293-304.
Post, Fink, Carpenter, Goodwin (1975) Cerebrospinal fluid amines metabolites in acute schizophrenia. Arch Gen Psychiatry 32:1063-1069.
Rallo, Perlin, Rostain, Lemaire (1989) Changes in ERPs components recorded under He-O2 and He-N2-O2 during a dive at 450 msw. High Pressure Nervous Syndrome, 20 Years Later , J.-C. Rostain, E. Martinez, C. Lemaire, ARAS-SNHP Publications, Marseilles; 51-57.
Raoul, Meliet, Broussolle (1988) Troubles psychiatriques et plongee profonde. Med Armees 16:269-270.
Reynolds (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305:527.
Seeman, Niznik (1990) Dopamine receptors and transporters in Parkinson's disease and schizophrenia. FASEB J 4:2737-2744.
Seeman, Niznik, Guan, Booth, Ulpian (1989) Link between D1 and D2 receptors is reduced in schizophrenia and Huntington diseased brain. Proc Natl Acad Sci USA 86:10156-10160.
Sherman, Davidson, Baruah, Hegwood, Warizi (1991) Evidence of glutamatergic deficiency in schizophrenia. Neurosci Lett 121:77-80.
Stoudemire, Miller, Schmitt (1984) Development of an organic affective syndrome during a hyperbaric diving experiment. Am J Psychiatry 141:1251-1254.
Suga, Kobayashi, Ogata, Toru (1990) Increased 3H-MK801 binding sites in post-mortem brains of chronic schizophrenic patients. New Trends in Schizophrenia and Mood Disorders Research , Kyoto; 28.
Tomei, Abraini, Rostain (1991) A new device for behavioral analysis on rats exposed to high pressure. Physiol Behav 49:393-396.
Walters, Bergstrom, Carlson, Chase, Braun (1987) D1 dopamine receptor activation required for post-synaptic expression of D2 agonist effects. Science 236:719-722.
Zinebi, Fagni, Hugon (1988) The influence of helium pressure on the reduction induced in the field potentials by various amino acids on the GABA-mediated inhibition on the CA 1 region of the hippocampal slices. Neuropharmacology 27:57-65.
