Pressure-Induced Disorders in Neurotransmission and Spontaneous Behavior in Rats: An Animal Model of Psychosis

[en] Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.

Disciplines :

Neurosciences & behavior

Author, co-author :

Abraini, Jacques H.

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Fechtali, T.

Language :

English

Title :

Pressure-Induced Disorders in Neurotransmission and Spontaneous Behavior in Rats: An Animal Model of Psychosis

Publication date :

01 November 1993

Journal title :

Biological Psychiatry

ISSN :

0006-3223

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

622-629

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 March 2021

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Bibliography

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