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Article (Scientific journals)
Trazodone in Benzodiazepine Dependence
Ansseau, Marc  ; De Roeck, J.
1993 • In Journal of Clinical Psychiatry, 54 (5), p. 189-191
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Keywords :
Benzodiazepines; Substance-related disorders; Trazodone; Drug administration schedule
Abstract :
[en] BACKGROUND: The authors set forth to test the usefulness of trazodone as an alternative anxiolytic in benzodiazepine-dependent patients. METHOD: Ten benzodiazepine-dependent patients according to DSM-III-R were hospitalized during a 2-4 week period and treated with trazodone (100 mg t.i.d.) while their benzodiazepine intake was progressively tapered; they left the hospital on a regimen of only a 300-mg daily dose of trazodone and were followed as outpatients at monthly intervals. The dose of trazodone was individually adapted according to condition. RESULTS: Very limited withdrawal phenomena occurred during the benzodiazepine taper period; during the 1-year follow-up, all patients remained off benzodiazepines and showed no evidence of abuse of trazodone. The dose of trazodone was significantly reduced to 185 mg (p = .003); the ratings of anxiety and depressive symptoms also significantly improved during follow-up: from 12.3 to 5.4 on the Hamilton Rating Scale for Anxiety (p = .002) and from 11.6 to 4.8 on the Hamilton Rating Scale for Depression (p = .002). CONCLUSION: These findings suggest the usefulness of trazodone as an alternative anxiolytic in patients at risk for benzodiazepine abuse.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
De Roeck, J.
Language :
Title :
Trazodone in Benzodiazepine Dependence
Publication date :
Journal title :
Journal of Clinical Psychiatry
Publisher :
Physicians Postgraduate Press, United States - Tennessee
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi


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