Article (Scientific journals)
Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways.
Machelart, Arnaud; Van Vyve, Margaux; Potemberg, Georges et al.
2017In Frontiers in Immunology, 8, p. 903
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Keywords :
Brucella abortus; Brucella melitensis; Mycobacterium tuberculosis; Trypanosoma brucei brucei; Trypanosoma cruzi; brucellosis; infection control
Abstract :
[en] This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T. brucei in natural hosts and mice models are well established, we observed that the injection of T. brucei in mice chronically infected with B. melitensis induces a drastic reduction in the number of B. melitensis in the spleen, the main reservoir of the infection. Similar results are obtained with Brucella abortus- and Brucella suis-infected mice and B. melitensis-infected mice co-infected with Trypanosoma cruzi, demonstrating that this phenomenon is not due to antigenic cross-reactivity. Comparison of co-infected wild-type and genetically deficient mice showed that Brucella elimination required functional IL-12p35/IFNγ signaling pathways and the presence of CD4(+) T cells. However, the impact of wild type and an attenuated mutant of T. brucei on B. melitensis were similar, suggesting that a chronic intense inflammatory reaction is not required to eliminate B. melitensis. Finally, we also tested the impact of T. brucei infection on the course of Mycobacterium tuberculosis infection. Although T. brucei strongly increases the frequency of IFNγ(+)CD4(+) T cells, it does not ameliorate the control of M. tuberculosis infection, suggesting that it is not controlled by the same effector mechanisms as Brucella. Thus, whereas T. brucei infections are commonly viewed as immunosuppressive and pathogenic, our data suggest that these parasites can specifically affect the immune control of Brucella infection, with benefits for the host.
Disciplines :
Microbiology
Author, co-author :
Machelart, Arnaud
Van Vyve, Margaux
Potemberg, Georges  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > STA Assurance qualité
Demars, Aurore
De Trez, Carl
Tima, Hermann Giresse
Vanwalleghem, Gilles
Romano, Marta
Truyens, Carine
Letesson, Jean-Jacques
Muraille, Eric
Language :
English
Title :
Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways.
Publication date :
2017
Journal title :
Frontiers in Immunology
eISSN :
1664-3224
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Volume :
8
Pages :
903
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 March 2021

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