Article (Scientific journals)
Investigation of inflammatory and allergic responses to common mold species: Results from in vitro experiments, from a mouse model of asthma, and from a group of asthmatic patients.
Vincent, Murielle; Percier, Pauline; De Prins, Sophie et al.
2017In Indoor Air, 27 (5), p. 933-945
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Keywords :
Air Microbiology; Air Pollution, Indoor; Alternaria/isolation & purification; Animals; Aspergillus/isolation & purification; Asthma/immunology; Bronchoalveolar Lavage Fluid; Cladosporium/isolation & purification; Cytokines/immunology; Female; Humans; Hypersensitivity/immunology; Immunoglobulin E/blood; Inflammation/immunology; Lung/pathology; Mice; Mice, Inbred C57BL; Penicillium/isolation & purification; asthma; dot-blot assay; indoor molds; inflammatory properties of molds; mold sensitization; mouse model of asthma
Abstract :
[en] Most studies on molds focus on Alternaria alternata and Aspergillus fumigatus. Here, we report on inflammatory and allergenic properties of more typical indoor species Aspergillus versicolor, P. chrysogenum, C. cladosporioïdes, and C. sphaerospermum that were compared to A. alternata and A. fumigatus. In a mouse model, after intranasal instillation, A. alternaria, A. versicolor, and C. sphaerospermum induced the early recruitment of neutrophils and the strong expression of inflammatory markers in the bronchoalveolar lavages fluids. A. fumigatus also induced the early accumulation of neutrophils but with lower levels of inflammatory markers. Chronic treatment induced variable response according to species: P. chrysogenum and A. fumigatus appeared strong pro-allergenic inducers compared to A. alternata and C. sphaerospermum while A. versicolor and C. cladosporioides induced a mixed pro-allergenic/pro-inflammatory response. In mold-sensitized asthmatics, mold-specific Immunoglobulin E (IgE) were detected with an in-house dot-blot assay. A. fumigatus and A. alternata were the most frequent sensitizers. Altogether, P. chrysogenum, P. brevicompactum, C. sphaerospermum, and C. cladosporïoides were the "major sensitizer" (defined as the strongest response against a single mold species) for almost 30% of the asthmatics. These results show that, not only A. alternata and A. fumigatus, but also indoor species have strong inflammatory and allergic properties and a harmful potency.
Disciplines :
Immunology & infectious disease
Author, co-author :
Vincent, Murielle
Percier, Pauline
De Prins, Sophie
Huygen, Kris
Potemberg, Georges  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > STA Assurance qualité
Romano, Marta
Michel, Olivier
Muraille, Eric
Denis, Olivier
Language :
English
Title :
Investigation of inflammatory and allergic responses to common mold species: Results from in vitro experiments, from a mouse model of asthma, and from a group of asthmatic patients.
Publication date :
2017
Journal title :
Indoor Air
ISSN :
0905-6947
eISSN :
1600-0668
Publisher :
Munksgaard International Publishers, Denmark
Volume :
27
Issue :
5
Pages :
933-945
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Available on ORBi :
since 16 March 2021

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