Visually induced analgesia during face or limb stimulation in healthy and migraine subjects

SAVA, Simona Liliana; DE PASQUA, Victor; MAERTENS DE NOORDHOUT, Alain; Schoenen, Jean

doi:10.2147/JPR.S160276

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Visually induced analgesia during face or limb stimulation in healthy and migraine subjects

SAVA, Simona Liliana; DE PASQUA, Victor; MAERTENS DE NOORDHOUT, Alain et al.

2018 • In Journal of Pain Research, 11, p. 1821-1828

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https://hdl.handle.net/2268/257717

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10.2147/JPR.S160276

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Keywords :

CHEPs; Migraine; Mirror therapy; Pain; Vision; Visually induced analgesia; Article

Abstract :

[en] Background: Visually induced analgesia (VIA) defines a phenomenon in which viewing one’s own body part during its painful stimulation decreases the perception of pain. VIA occurs during direct vision of the stimulated body part and also when seeing it reflected in a mirror. To the best of our knowledge, VIA has not been studied in the trigeminal area, where it could be relevant for the control of headache. Subjects and methods: We used heat stimuli (53°C) to induce pain in the right forehead or wrist in 11 healthy subjects (HSs) and 14 female migraine without aura (MO) patients between attacks. The subjects rated pain on a visual analog scale (VAS) and underwent contact heat-evoked potential (CHEP) recordings (five sequential blocks of four responses) with or without observation of their face/wrist in a mirror. Results: During wrist stimulation, amplitude of the first block of P1–P2 components of CHEPs decreased compared to that in the control recording when HSs were seeing their wrist reflected in the mirror (p = 0.036; Z = 2.08); however, this was not found in MO patients. In the latter, the VAS pain score increased viewing the reflected wrist (p = 0.049; Z = 1.96). Seeing their forehead reflected in the mirror induced a significant increase in N2 latency of CHEPs in HSs, as well as an amplitude reduction in the first block of P1–P2 components of CHEPs both in HSs (p = 0.007; Z = 2.69) and MO patients (p = 0.035; Z = 2.10). Visualizing the body part did not modify habituation of CHEP amplitudes over the five blocks of averaged responses, neither during wrist nor during forehead stimulation. Conclusion: This study adds to the available knowledge on VIA and demonstrates this phenomenon for painful stimuli in the trigeminal area, as long as CHEPs are used as indices of central pain processing. In migraine patients during interictal periods, VIA assessed with CHEPs is within normal limits in the face but absent at the wrist, possibly reflecting dysfunctioning of extracephalic pain control. © 2018 Sava et al.

Disciplines :

Neurology

Author, co-author :

SAVA, Simona Liliana ; Headache Clinic of Valdor-ISOSL, Liège, Belgium

DE PASQUA, Victor ; Headache Research Unit, Department of Neurology, Liège University, Liège, Belgium

MAERTENS DE NOORDHOUT, Alain ; Headache Research Unit, Department of Neurology, Liège University, Liège, Belgium

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Language :

English

Title :

Visually induced analgesia during face or limb stimulation in healthy and migraine subjects

Publication date :

2018

Journal title :

Journal of Pain Research

eISSN :

1178-7090

Publisher :

Dove Medical Press Ltd.

Volume :

Pages :

1821-1828

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 March 2021

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Bibliography

Mouraux A, Diukova A, Lee MC, et al. A multisensory investigation of the functional significance of the “pain matrix”. Neuroimage. 2011;54(3):2237–2249.
Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–979.
Tipper SP, Lloyd D, Shorland B, Dancer C, Howard LA, McGlone F. Vision influences tactile perception without proprioceptive orienting. Neuroreport. 1998;9(8):1741–1744.
Kennett S, Taylor-Clarke M, Haggard P. Non informative vision improves the spatial resolution of touch in humans. Curr Biol. 2001;11(15): 1188–1191.
Taylor-Clarke M, Kennett S, Haggard P. Vision modulates somatosensory cortical processing. Curr Biol. 2002;12:233–236.
Wall PD, Sweet WH. Temporary abolition of pain in man. Science. 1967;155(3758):108–109.
Higgens JD, Tursky B, Schwartz GE. Shock-elicited pain and its reduction by concurrent tactile stimulation. Science. 1971;172(3985):866–867.
Lundeberg T. Relief of pain from a phantom limb by peripheral stimulation. J Neurol. 1985;232(2):79–82.
Inui K, Tsuji T, Kakigi R. Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans. Cereb Cortex. 2006;16(3): 355–365.
Flor H, Denke C, Schaefer M, et al. Effect of sensory discrimination training on cortical reorganization and phantom limb pain. Lancet. 2001;357:1763–1764.
Moseley GL, Zalucki NM, Wiech K. Tactile discrimination, but not tactile stimulation alone, reduces chronic limb pain. Pain. 2008;137:600–608.
Moseley GL, Wiech K. The effect of tactile discrimination training is enhanced when patients watch the reflected image of their unaffected limb during training. Pain. 2009;144(3):314–319.
Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996;263(1369):377–386.
Chan BL, Witt R, Charrow AP, et al. Mirror therapy for phantom limb pain. N Engl J Med. 2007;357:2206–2207.
Weeks SR, Anderson-Barnes VC, Tsao JW. Phantom limb pain: theories and therapies. Neurologist. 2010;16:277–286.
Kawashima N, Mita T, Yoshikawa M. Inter-individual difference in the effect of mirror reflection-induced visual feedback on phantom limb awareness in forearm amputees. PLoS One. 2013;8(7):e69324.
Foell J, Bekrater-Bodmann R, Diers M, Flor H. Mirror therapy for phantom limb pain: brain changes and the role of body representation. Eur J Pain. 2014;18(5):729–739.
Rothgangel AS, Braun SM, Beurskens AJ, Seitz RJ, Wade DT. The clinical aspects of mirror therapy in rehabilitation: a systematic review of the literature. Int J Rehabil Res. 2001;34(1):1–13.
Ezendam D, Bongers RM, Jannink MJ. Systematic review of the effectiveness of mirror therapy in upper extremity function. Disabil Rehabil. 2009;31(26):2135–2149.
Thieme H, Mehrholz J, Pohl M, Behrens J, Dohle C. Mirror therapy for improving motor function after stroke. Stroke. 2013;44(1):e1–e2.
Longo MR, Betti V, Aglioti SM, Haggard P. Visually induced analgesia: seeing the body reduces pain. J Neurosci. 2009;29(39):12125–12130.
Longo MR, Iannetti GD, Mancini F, Driver J, Haggard P. Linking pain and the body: neural correlates of visually induced analgesia. J Neurosci. 2012;32(8):2601–2607.
Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain. 2013;154(suppl 1).
Sava SL, de Pasqua V, Magis D, Schoenen J. Effects of visual cortex activation on the nociceptive blink reflex in healthy subjects. PLoS One. 2014;9(6):e100198.
Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.
de Tommaso M, Valeriani M, Sardaro M, et al. Pain perception and laser evoked potentials during menstrual cycle in migraine. J Headache Pain. 2009;10(6):423–429.
Magerl W, Ali Z, Ellrich J, Meyer RA, Treede RD. C-and A delta-fiber components of heat-evoked cerebral potentials in healthy human subjects. Pain. 1999;82(2):127–137.
Price DD. Selective activation of A-delta and C nociceptive afferents by different parameters of nociceptive heat stimulation: a tool for analysis of central mechanisms of pain. Pain. 1996;68:1–3.
Chen AC, Niddam DM, Arendt-Nielsen L. Contact heat evoked potentials as a valid means to study nociceptive pathways in human subjects. Neurosci Lett. 2001;316(2):79–82.
Valeriani M, Le Pera D, Niddam D, Chen AC, Arendt-Nielsen L. Dipolar modelling of the scalp evoked potentials to painful contact heat stimulation of the human skin. Neurosci Lett. 2002;318(1):44–48.
Granovsky Y, Matre D, Sokolik A, Lorenz J, Casey KL. Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis. Pain. 2005;115(3):238–247.
Granovsky Y, Anand P, Nakae A, et al. Normative data for Aδ contact heat evoked potentials in adult population: a multicenter study. Pain. 2016;157(5):1156–1163.
Ruscheweyh R, Emptmeyer K, Putzer D, Kropp P, Marziniak M. Repro-ducibility of contact heat evoked potentials (CHEPs) over a 6 months interval. Clin Neurophysiol. 2013;124(11):2242–2247.
Berkley KJ. Sex differences in pain. Behav Brain Sci. 1997;20:371–380.
Fillingim R, Edwards R, Powell T. Sex-dependent effects of reported familial pain history on recent pain complaints and experimental pain responses. Pain. 2000;86:87–94.
Fillingim RB, Maixner W. The influence of resting blood pressure and gender on pain responses. Psychosom Med. 1996;58(4):326–332.
Riley JL 3rd, Robinson ME, Wise EA, Myers CD, Fillingim RB. Sex differences in the perception of noxious experimental stimuli: a meta-analysis. Pain. 1998;74(2–3):181–187.
Shinal R, Fillingim R. Overview of orofacial pain: epidemiology and gender differences in orofacial pain. Dent Clin North Am. 2007;51(1): 1–18.
Vigil JM, Strenth CR, Mueller AA, et al. The curse of curves: sex differences in the associations between body shape and pain expression. Hum Nat. 2015;26(2):235–254.
Iannetti GD, Hughes NP, Lee MC, Mouraux A. Determinants of laser-evoked EEG responses: pain perception or stimulus saliency? J Neurophysiol. 2008;100(2):815–828.
de Tommaso M, Ricci K, Montemurno A, Vecchio E. Age-related changes in laser-evoked potentials following trigeminal and hand stimulation in healthy subjects. Eur J Pain. 2017;21(6):1087–1097.
Carmon A, Friedman Y, Coger R, Kenton B. Single trial analysis of evoked potentials to noxious thermal stimulation in man. Pain. 1980;8(1): 21–32.
Mouraux A, Iannetti GD, Plaghki L. Low intensity intra-epidermal electrical stimulation can activate Aδ-nociceptors selectively. Pain. 2010;150(1):199–207.
Dionne JK, Meehan SK, Legon W, Staines WR. Crossmodal influences in somatosensory cortex: interaction of vision and touch. Hum Brain Mapp. 2010;31(1):14–25.
Mancini F, Bolognini N, Haggard P, Vallar G. tDCS modulation of visually induced analgesia. J Cogn Neurosci. 2012;24(12):2419–2427.
Imbert M, Bignall KE. Projections visuelles corticales chez le Chat thalameclomisé à l’exception du corps genouillé latéral [Projections from the visual cortex in the thalamectomized cat with the exception of the lateral geniculate body]. J Physiol (Paris). 1965;57:252–253.
Coppola G, Di Lorenzo C, Schoenen J, Pierelli F. Habituation and sensitization in primary headaches. J Headache Pain. 2013;14:65.
Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol. 2000;47(5):614–624.
Manack A, Buse DC, Serrano D, Turkel CC, Lipton RB. Rates, predictors, and consequences of remission from chronic migraine to episodic migraine. Neurology. 2011;76(8):711–718.
de Tommaso M, Ambrosini A, Brighina F, et al. Altered processing of sensory stimuli in patients with migraine. Nat Rev Neurosci. 2014;10(3):144–155.
de Tommaso M, Libro G, Guido M, Losito L, Lamberti P, Livrea P. Habituation of single CO2 laser-evoked responses during interictal phase of migraine. J Headache Pain. 2005;6(4):195–198.
Lev R, Granovsky Y, Yarnitsky D. Enhanced pain expectation in migraine: EEG-based evidence for impaired prefrontal function. Headache. 2013;53(7):1054–1070.
Beese LC, Putzer D, Osada N, Evers S, Marziniak M. Contact heat evoked potentials and habituation measured interictally in migraineurs. J Headache Pain. 2015;16:1.