The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

LOMBARD, Arnaud; Di Gregorio, Marina; Delcamp, Clément; Rogister, Bernard; Piette, Caroline; Coppieters't Wallant, Natacha

doi:10.3389/fonc.2020.614930

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The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

LOMBARD, Arnaud; Di Gregorio, Marina; Delcamp, Clément et al.

2021 • In Frontiers in Oncology

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https://hdl.handle.net/2268/257707

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10.3389/fonc.2020.614930

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Keywords :

Gliomas; glioblastoma; recurrence; cancer stem cells; subventricular zone

Abstract :

[en] Both in adult and children, high-grade gliomas (WHO grades III and IV) account for a high proportion of death due to cancer. This poor prognosis is a direct consequence of tumor recurrences occurring within few months despite a multimodal therapy consisting of a surgical resection followed by chemotherapy and radiotherapy. There is increasing evidence that glioma stem cells (GSCs) contribute to tumor recurrences. In fact, GSCs can migrate out of the tumor mass and reach the subventricular zone (SVZ), a neurogenic niche persisting after birth. Once nested in the SVZ, GSCs can escape a surgical intervention and resist to treatments. The present review will define GSCs and describe their similarities with neural stem cells, residents of the SVZ. The architectural organization of the SVZ will be described both for humans and rodents. The migratory routes taken by GSCs to reach the SVZ and the signaling pathways involved in their migration will also be described hereafter. In addition, we will debate the advantages of the microenvironment provided by the SVZ for GSCs and how this could contribute to tumor recurrences. Finally, we will discuss the clinical relevance of the SVZ in adult GBM and pediatric HGG and the therapeutic advantages of targeting that neurogenic region in both clinical situations.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

LOMBARD, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de neurochirurgie

Di Gregorio, Marina ; Université de Liège - ULiège > GIGA

Delcamp, Clément ; Université de Liège - ULiège > Neurosciences-Nervous system disorders and therapy

Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Piette, Caroline ; Université de Liège - ULiège > Département des sciences cliniques > Neuropédiatrie

Coppieters't Wallant, Natacha ; Université de Liège - ULiège > Neurosciences-Nervous system disorders and therapy

Language :

English

Title :

The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

Publication date :

26 January 2021

Journal title :

Frontiers in Oncology

eISSN :

2234-943X

Publisher :

Frontiers Media S.A., Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 March 2021

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