Diagnostic and Prognostic Biomarkers for Chronic Fibrosing Interstitial Lung Diseases With a Progressive Phenotype

C-C motif chemokine 18; Clara cell protein; CXCL13 chemokine; HLA antigen; Krebs von den Lungen 6; FAM13A gene; MUCB5 gene; Review; RTEL1 gene; TERC gene; TERT gene; TOLLIP gene

Abstract :

[en] Biomarkers have the potential to become central to the clinical evaluation and monitoring of patients with chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype. Here we summarize the current understanding of putative serum, BAL fluid, and genetic biomarkers in this setting, according to their hypothesized pathobiologic mechanisms: evidence of epithelial cell dysfunction (eg, Krebs von den Lungen-6 antigen), fibroblast proliferation and extracellular matrix production or turnover (eg, matrix metalloproteinase-1), or immune dysregulation (eg, CC chemokine ligand 18). While most of the available data come from idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrosing ILD, data are available in the broader patient population of chronic fibrosing ILDs. A number of these biomarkers show promise, however, none have been validated. In this review article, we assess both the status of proposed biomarkers for chronic fibrosing lung diseases with a progressive phenotype in predicting disease risk or predisposition, diagnosis, prognosis, and treatment response and provide a direct comparison between IPF and other chronic fibrotic ILDs. We also reflect on the current clinical usefulness and future direction of research for biomarkers in the setting of chronic fibrosing ILDs with a progressive phenotype. © 2020 The Authors

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Inoue, Y.; Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan

Kaner, R. J.; Pulmonary and Critical Care Medicine, Genetic Medicine, Weill Cornell Medicine College, New York, NY, United States

Guiot, Julien ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Maher, T. M.; NIHR Respiratory Clinical Research Facility, Royal Brompton Hospital, and Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London, England, United Kingdom

Tomassetti, S.; Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy

Moiseev, S.; Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russian Federation

Kuwana, M.; Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan

Brown, K. K.; Department of Medicine, National Jewish Health, Denver, CO, United States

Language :

English

Title :

Diagnostic and Prognostic Biomarkers for Chronic Fibrosing Interstitial Lung Diseases With a Progressive Phenotype

Publication date :

August 2020

Journal title :

CHEST

ISSN :

0012-3692

eISSN :

1931-3543

Publisher :

Elsevier Inc

Volume :

158

Issue :

Pages :

646-659

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://pubmed.ncbi.nlm.nih.gov/32268131/

Funders :

Boehringer Ingelheim

Available on ORBi :

since 05 March 2021

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