Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

TCHANA-SATO, Vincent; ANCION, Arnaud; TRIDETTI, Julien; Sakalihasan, Natzi; Hayette, Marie-Pierre; Detry, Olivier; Delvenne, Philippe; AMABILI, Philippe; Senard, Marc; HOUGRAND, Olivier; SZECEL, Delphine; LAVIGNE, Jean-Paul; Minga Lowampa, Elie; Ponte, Charlotte; MAQUOI, Isabelle; Morimont, Philippe; VAN DEN BULCK, Mélissa; DELBOUILLE, Marie-Hélène; Defraigne, Jean-Olivier; Lancellotti, Patrizio

doi:10.1186/s12879-021-05793-6

Article (Scientific journals)

Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

TCHANA-SATO, Vincent; ANCION, Arnaud; TRIDETTI, Julien et al.

2021 • In BMC Infectious Diseases

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/257630

DOI
10.1186/s12879-021-05793-6

PubMed
33472599

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Keywords :

severe acute respiratory syndrome coronavirus 2; Coronavirus disease 2019; heart transplantation

Abstract :

[en] Background: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation: This report describes the clinical course and the challenging management of early COVID-19infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions: These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed.

Disciplines :

Microbiology

Author, co-author :

TCHANA-SATO, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de chirurgie cardio-vasculaire et thoracique

ANCION, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Insuffisance cardiaque - Transplantation

TRIDETTI, Julien ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de cardiologie

Sakalihasan, Natzi ; Université de Liège - ULiège > Département des sciences cliniques > Biologie pathologique des parois artérielles

Hayette, Marie-Pierre ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Bact., mycologie, parasitologie, virologie, microbio.

Detry, Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne

Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

AMABILI, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Senard, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

HOUGRAND, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire microscopie électronique

More authors (10 more)

Language :

English

Title :

Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

Publication date :

January 2021

Journal title :

BMC Infectious Diseases

eISSN :

1471-2334

Publisher :

BioMed Central, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 March 2021

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