Article (Scientific journals)
Proteinuria in COVID‑19: prevalence, characterization and prognostic role
HUART, Justine; BOUQUEGNEAU, Antoine; Lutteri, Laurence et al.
2021In Journal of Nephrology, 34 (3), p. 355-364
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Keywords :
Proteinuria; COVID-19; alpha1-microglobulin; Tutubar protéinuria
Abstract :
[en] Abstract Background Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantifcation and characterization of proteinuria were investigated and their association with mortality was assessed. Methods This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α1-microglobulin (a marker of tubular injury) were measured. Association with mortality was evaluated, with a follow-up until May 7th, 2020. Results According to the Kidney Disease Improving Global Outcomes staging, 14% (n=21) of the patients had category 1 proteinuria (<150 mg/g of urine creatinine), 42% (n=64) had category 2 (between 150 and 500 mg/g) and 44% (n=68) had category 3 proteinuria (over 500 mg/g). Urine α1-microglobulin concentration was higher than 15 mg/g in 89% of patients. After a median follow-up of 27 [14;30] days, the mortality rate reached 18%. Total proteinuria and urinary α1-microglobulin were associated with mortality in unadjusted and adjusted models. This association was stronger in subgroups of patients with normal renal function and without a urinary catheter. Conclusions Proteinuria is frequent in patients with COVID-19. Its characterization suggests a tubular origin, with increased urinary α1-microglobulin. Tubular proteinuria was associated with mortality in COVID-19 in our restropective, observational study.
Disciplines :
Urology & nephrology
Public health, health care sciences & services
Laboratory medicine & medical technology
Management information systems
Anesthesia & intensive care
Author, co-author :
HUART, Justine  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
BOUQUEGNEAU, Antoine  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Lutteri, Laurence ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
ERPICUM, Pauline ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
GROSCH, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Résimont, Guillaume ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
WIESEN, Patricia ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service des soins intensifs
BOVY, Christophe ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
THYS, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur exploitation des données
LAMBERMONT, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service des soins intensifs
Misset, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service des soins intensifs
Pottel, Hans ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Mariat, Christophe;  Hôpital Nord, CHU de Saint-Etienne, Université Jean Monnet, Lyon - France > Nephrologie, dialyse et transplantation rénale
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de chimie clinique
Burtey, Stéphane;  Public Assistance of the Hospitals of Marseille, Marseille, France > Center of Nephrology and Renal Transplantation
Jouret, François  ;  Université de Liège - ULiège > Cardiovascular Sc.-Lab. of Translational Res. in Nephrology
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
More authors (8 more) Less
Language :
English
Title :
Proteinuria in COVID‑19: prevalence, characterization and prognostic role
Publication date :
23 January 2021
Journal title :
Journal of Nephrology
ISSN :
1121-8428
eISSN :
1724-6059
Publisher :
Wichtig Publishing, Italy
Volume :
34
Issue :
3
Pages :
355-364
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 February 2021

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