Final Height in Children with Idiopathic Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: The Belgian Experience

Thomas, M.; Massa, G.; Bourguignon, Jean-Pierre; Craen, M.; De Schepper, J.; de Zegher, F.; Dooms, L.; Du Caju, M.; Francois, I.; Heinrichs, C.; Malvaux, P.; Rooman, R.; Thiry-Counson, G.; Vandeweghe, M.; Maes, M.

doi:10.1159/000049976

Article (Scientific journals)

Final Height in Children with Idiopathic Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: The Belgian Experience

Thomas, M.; Massa, G.; Bourguignon, Jean-Pierre et al.

2001 • In Hormone Research in Paediatrics, 55 (2), p. 88-94

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https://hdl.handle.net/2268/257205

DOI
10.1159/000049976

PubMed
11509865

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Keywords :

Growth hormone deficiency; Growth hormone treatment; Final height; Idiopathic hypopituitarism; Puberty; Belgium

Abstract :

[en] BACKGROUND: The growth response to recombinant hGH (rhGH) treatment and final height of 61 Belgian children (32 boys) with idiopathic growth hormone deficiency (GHD) were studied. PATIENTS/METHODS: Two patient groups were compared: Group 1 with spontaneous puberty (n = 49), Group 2 with induced puberty (n = 12). The patients were treated with daily subcutaneous injections of rhGH in a dose of 0.5-0.7 IU/kg/week (0.17-0.23 mg/kg/week) from the mean +/- SD age of 11.9 +/- 3.1 years during 5.1 +/- 2.1 years. RESULTS: rhGH treatment induced a doubling of the height velocity during the first year and resulted in a normalisation of height in 53 (87%) patients. Final height was -0.7 +/- 1.1 SDS, being 170.4 +/- 7.2 cm in boys and 158.0 +/- 6.4 cm in girls. Corrected for mid-parental height, final height was 0.0 +/- 1.1 SDS. Ninety-two percent of the patients attained an adult height within the genetically determined target height range. Although height gain during puberty was smaller in the patients with induced puberty (boys: 17.1 +/- 7.0 cm vs. 27.5 +/- 6.6 cm (p < 0.005); girls: 9.6 +/- 7.4 cm vs. 22.2 +/- 6.1 cm (p < 0.005)), no differences in final height after adjustment for mid-parental height were found between patients with spontaneous or induced puberty. CONCLUSIONS: We conclude that patients with idiopathic GHD treated with rhGH administered as daily subcutaneous injections in a dose of 0.5-0.7 IU/kg/week reach their genetic growth potential, resulting in a normalisation of height in the majority of them, irrespective of spontaneous or induced puberty. Copyright © 2001 S. Karger AG, Basel

Research Center/Unit :

The Belgian Study Group for Paediatric Endocrinology - BSGPE

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Thomas, M.

Massa, G.

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Craen, M.

De Schepper, J.

de Zegher, F.

Dooms, L.

Du Caju, M.

Francois, I.

Heinrichs, C.

More authors (5 more)

Language :

English

Title :

Final Height in Children with Idiopathic Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: The Belgian Experience

Publication date :

2001

Journal title :

Hormone Research in Paediatrics

ISSN :

1663-2818

eISSN :

1663-2826

Publisher :

Karger, Basel, Switzerland

Volume :

Issue :

Pages :

88-94

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

The Foundation of the Belgian Study Group for Paediatric Endocrinology

Available on ORBi :

since 22 February 2021

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Bibliography

Vanderschueren-Lodeweyckx M., Van den Broeck J., Wolter R., Malvaux P. (1987) Early initiation of growth hormone treatment: Influence on final height. Acta Paediatr Scand 337(SUPPL.):4-11.
Bourguignon J.-P., Vandeweghe M., Vanderschueren-Lodeweyckx M., Malvaux P., Wolter R., Du Caju M., Ernould C. (1986) Pubertal growth and final height in hypopituitary boys: A minor role of bone age at onset of puberty. J Clin Endocrinol Metab 63:376-382.
Kastrup K.W., Christiansen S., Andersen K.J., Orskov H. (1983) Increased growth rate following transfer to daily s.c. administration from three weekly i.m. injections of hGH in growth hormone deficient children. Acta Endocrinol 104:148-152.
Wilson D.M., Baker B., Hintz R., Rosenfeld R.G. (1985) Subcutaneous versus intramuscular growth hormone therapy: Growth and acute somatomedin response. Pediatrics 76:361-364.
Smith P.J., Hindmarsh P.C., Brook C.G.D. (1988) Contribution of dose and frequency of administration to the therapeutic effects of growth hormone. Arch Dis Child 63:491-494.
Brämswig J.H., Schlösser H., Kiese K. (1995) Final height in children with growth hormone deficiency. Horm Res 43:126-128.
Blethen S.L., Baptista J., Kuntze L., Foley T., LaFranchi S., Johanson A. (1997) Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. J Clin Endocrinol Metab 82:418-420.
Cacciari E., Cicognani A., Pirazzoli P. (1997) Final height of patients treated for isolated GH deficiency: Examination of 83 patients. Eur J Endocrinol 137:53-60.
Cutfield W., Lindberg A., Albertson-Wikland K., Chatelain P., Ranke M.B., Wilton P. (1999) Final height in idiopathic growth hormone deficiency: The KIGS experience. KIGS international Board. Acta Paediatr 88(SUPPL. 428):72-75.
Thomas M., Maes M., Bourguignon J.P. (2000) Interruption of GH treatment and early retesting has little value in isolated GH deficiency. Horm Res 53(SUPPL. 2).
Tanner J.M., Whitehouse R.H., Takaishi M. (1966) Standards from birth to maturity for height, weight, height velocity and weight velocity: British children 1965. Arch Dis Child 41:454-471.
Tanner J.M. Growth and Adolescence, Blackwell, Oxford; 1962.
Zachmann M., Prader A., Kind H.P., Hafliger H., Budliger H. (1974) Testicular volume during adolescence. Cross-sectional and longitudinal studies. Helv Paediatr Acta 39:61-72.
Tanner J.M., Whitehouse R.H., Cameron N., Marshall W.A., Healy M.J.R., Goldstein H. Assessment of Skeletal Maturity and Prediction of Adult Height (TW2 Method), ed 2, London, Academic Press; 1983.
Greulich W.W., Pyle S.I. Radiographic atlas of skeletal development of the hand and wrist, ed 2, Stanford, Stanford University Press; 1959.
Milner G.R., Levick R.K., Kay R. (1986) Assessment of bone age: A comparison of the Greulich and Pyle, and Tanner and Whitehouse methods. Clin Radiol 37:119-121.
Niklasson A., Ericson A., Fryer J.G., Karlberg J., Lawrence C., Karlberg P. (1991) An update of the Swedish reference standards for weight, length and head circumference at birth for given gestational age (1977-1981). Acta Paediatr Scand 80:756-762.
Cole T.J. (1996) Some questions about how growth standards are used. Horm Res 45(SUPPL. 2):18-23.
Ranke M.B. (1996) Towards a consensus on the definition of idiopathic short stature. Horm Res 45(SUPPL. 2):64-66.
Chipman J.J., Hicks J.R., Holcombe J.H., Draper M.W. (1995) Approaching final height in children treated for growth hormone deficiency. Horm Res 43:129-131.
Frisch H., Birnbacher R. (1995) Final height and pubertal development in children with growth hormone deficiency after long-term treatment. Horm Res 43:132-134.
Rikken B., Massa G., Wit M. (1995) Final height in a large cohort of dutch patients with growth hormone deficiency treated with growth hormone. Horm Res 43:135-137.
Severi F. (1995) Final height in children with growth hormone deficiency. Horm Res 43:138-140.
De Luca F., Maghnie M., Arrigo T., Lombardo F., Messina M.F., Bernasconi S. (1996) Final height outcome of growth hormone-deficient patients treated since less than five years of age. Acta Paediatr 85:1167-1171.
Ranke M., Price D., Albertsson-Wikland K., Maes M., Lindberg A. (1997) Factors determining pubertal growth and final height in growth hormone treatment of idiopathic growth hormone deficiency. Horm Res 48:62-71.
August G.P., Julius J.R., Blethen S.L. (1998) Adult height in children with growth hormone deficiency who are treated with biosynthetic growth hormone: The National Cooperative Growth Study Experience. Pediatrics 102:512-516.
Prader A., Largo R.H., Molinari L., Issler C. (1989) Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development. Helv Paediatr Acta 52:1-125.
Hamil P.V.V., Drizd T.A., Johnson C.L., Reed R.B., Roche A.F., Moore W.M. (1979) Physical growth: National center for health statistics percentiles. Am J Clin Nutr 32:607-629.
Massa G., Vanderschueren-Lodeweyckx M., Malvaux P. (1990) Growth in Turner syndrome: Influence of spontaneous puberty and parental height. Eur J Pediatr 149:246-250.
Van den Broeck J., Massa G.G., Attanasio A., Matranga A., Chaussain J.-L., Price D.A., Aarskog D., Wit J.M. (1995) Final height after long-term growth hormone treatment in Turner syndrome. J Pediatr 127:729-735.
Bernasconi S., Arrigo T., Wasniewsk M., Ghizzoni L., Ruggeri C., Di Pasquale G., Vottero A., De Luca F. (2000) Long-term results with growth hormone therapy in idiopathic hypopituitarism. Horm Res 53(SUPPL. 1):55-59.
Wacharasindhu S., Cotterill A.M., Camacho-Hübner C., Besser G.M., Savage M.O. (1996) Normal growth hormone secretion in growth hormone insufficient children retested after completion of linear growth. Clin Endocrinol 45:553-556.
Tauber M., Moulin P., Pienkowski C., Jouret B., Rochicciolo P. (1997) Growth hormone (GH) retesting and auxological data in 131 GH-deficient patients after completion of treatment. J Clin Endocrinol Metab 82:352-356.
Thomas M., Maes M., Ernould C., Bourguignon J.-P. (1999) L'insuffisance en hormone de croissance: Etiologie et révision diagnostique aprés la fin de la croissance. J Pédiatr Belg 1:155-160.
Mericq M.V., Eggers M., Avila A., Cutler G.B., Cassorla F. (2000) Near final height in pubertal growth hormone (GH)-deficient patients treated with GH alone or in combination with luteinizing hormone-releasing hormone analog: Results of a prospective, randomized trial. J Clin Endocrinol Metab 85:569-573.
Lagrou K., Xhrouet-Heinrichs D., Craen M. (1999) Psychosocial well-being in childhood onset growth hormone deficient (GHD) patients after the end of hGH therapy. Horm Res 51(SUPPL. 2):47.