Final Height in Children with Idiopathic Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: The Belgian Experience

Thomas, M.; Massa, G.; Bourguignon, Jean-Pierre; Craen, M.; De Schepper, J.; de Zegher, F.; Dooms, L.; Du Caju, M.; Francois, I.; Heinrichs, C.; Malvaux, P.; Rooman, R.; Thiry-Counson, G.; Vandeweghe, M.; Maes, M.

doi:10.1159/000049976

Article (Scientific journals)

Final Height in Children with Idiopathic Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: The Belgian Experience

Thomas, M.; Massa, G.; Bourguignon, Jean-Pierre et al.

2001 • In Hormone Research in Paediatrics, 55 (2), p. 88-94

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https://hdl.handle.net/2268/257205

DOI
10.1159/000049976

PubMed
11509865

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Keywords :

Growth hormone deficiency; Growth hormone treatment; Final height; Idiopathic hypopituitarism; Puberty; Belgium

Abstract :

[en] BACKGROUND: The growth response to recombinant hGH (rhGH) treatment and final height of 61 Belgian children (32 boys) with idiopathic growth hormone deficiency (GHD) were studied. PATIENTS/METHODS: Two patient groups were compared: Group 1 with spontaneous puberty (n = 49), Group 2 with induced puberty (n = 12). The patients were treated with daily subcutaneous injections of rhGH in a dose of 0.5-0.7 IU/kg/week (0.17-0.23 mg/kg/week) from the mean +/- SD age of 11.9 +/- 3.1 years during 5.1 +/- 2.1 years. RESULTS: rhGH treatment induced a doubling of the height velocity during the first year and resulted in a normalisation of height in 53 (87%) patients. Final height was -0.7 +/- 1.1 SDS, being 170.4 +/- 7.2 cm in boys and 158.0 +/- 6.4 cm in girls. Corrected for mid-parental height, final height was 0.0 +/- 1.1 SDS. Ninety-two percent of the patients attained an adult height within the genetically determined target height range. Although height gain during puberty was smaller in the patients with induced puberty (boys: 17.1 +/- 7.0 cm vs. 27.5 +/- 6.6 cm (p < 0.005); girls: 9.6 +/- 7.4 cm vs. 22.2 +/- 6.1 cm (p < 0.005)), no differences in final height after adjustment for mid-parental height were found between patients with spontaneous or induced puberty. CONCLUSIONS: We conclude that patients with idiopathic GHD treated with rhGH administered as daily subcutaneous injections in a dose of 0.5-0.7 IU/kg/week reach their genetic growth potential, resulting in a normalisation of height in the majority of them, irrespective of spontaneous or induced puberty. Copyright © 2001 S. Karger AG, Basel

Research Center/Unit :

The Belgian Study Group for Paediatric Endocrinology - BSGPE

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Thomas, M.

Massa, G.

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Craen, M.

De Schepper, J.

de Zegher, F.

Dooms, L.

Du Caju, M.

Francois, I.

Heinrichs, C.

More authors (5 more)

Language :

English

Title :

Final Height in Children with Idiopathic Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: The Belgian Experience

Publication date :

2001

Journal title :

Hormone Research in Paediatrics

ISSN :

1663-2818

eISSN :

1663-2826

Publisher :

Karger, Basel, Switzerland

Volume :

Issue :

Pages :

88-94

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

The Foundation of the Belgian Study Group for Paediatric Endocrinology

Available on ORBi :

since 22 February 2021

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