Article (Scientific journals)
Topical Ganciclovir Reduces Viral Excretion in Mares With Equine Coital Exanthema
Vissani, M. A.; Perglione, C. O.; Zabal, O. et al.
2020In Journal of Equine Veterinary Science, 94
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Keywords :
Antiviral; Coital; Equid alphaherpesvirus 3; Exanthema; Ganciclovir; Topical; Article; Equid herpesvirus 3
Abstract :
[en] Equid alphaherpesvirus 3 (EHV-3) is the etiological agent of equine coital exanthema (ECE). Because no vaccines or antiviral therapies are available, prevention consists of clinical examination of mares and stallions before mating or semen collection and resting from breeding activities when lesions are present. However, this methodology does not identify subclinically infected animals. Ganciclovir is the most potent compound known to reduce EHV-3 replication. This study aimed to evaluate the efficacy of topical ganciclovir application to reduce EHV-3 replication in experimentally infected mares. A pilot study, after a double-blind completely randomized design, was carried out. Twenty mares were randomly divided into five groups (three treated with ganciclovir with different regimen of doses, one treated with a placebo, and one nontreated). Mares were experimentally infected with EHV-3 on day 0. Rectal temperature, clinical signs, and lesions were recorded. Daily perineal and vaginal swabs were evaluated by quantitative polymerase chain reaction for virus detection. The antibody response was assessed by a virus neutralization test in serum samples collected weekly. Mares experimentally infected with EHV-3 and treated with ganciclovir twice a day for 13 days showed reduced levels and duration of viral excretion and less severe lesions. The viral excretion period was reduced from 18 to nine days compared with the untreated groups. We concluded that ganciclovir had an antiviral effect on EHV-3 replication when topically administered in mares showing clinical signs of ECE. Further trials should be performed to optimize the dose of the antiviral for a definitive formulation. © 2020
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Vissani, M. A.;  Instituto de Virología e Innovaciones Tecnológicas (IVIT), Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina, Cátedra de Enfermedades Infecciosas, Escuela de Veterinaria, Universidad del Salvador, Buenos Aires, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) scientific career, Buenos Aires, Argentina
Perglione, C. O.;  Instituto de Virología e Innovaciones Tecnológicas (IVIT), Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina
Zabal, O.;  Instituto de Virología e Innovaciones Tecnológicas (IVIT), Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina, Cátedra de Enfermedades Infecciosas, Escuela de Veterinaria, Universidad del Salvador, Buenos Aires, Argentina
Alvarez, G.;  Dirección de Remonta y Veterinaria, Ejército Argentino, Buenos Aires, Argentina
Thiry, Etienne ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales
Barrandeguy, M.;  Instituto de Virología e Innovaciones Tecnológicas (IVIT), Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina, Cátedra de Enfermedades Infecciosas, Escuela de Veterinaria, Universidad del Salvador, Buenos Aires, Argentina
Parreño, V.;  Instituto de Virología e Innovaciones Tecnológicas (IVIT), Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) scientific career, Buenos Aires, Argentina
Language :
English
Title :
Topical Ganciclovir Reduces Viral Excretion in Mares With Equine Coital Exanthema
Publication date :
2020
Journal title :
Journal of Equine Veterinary Science
ISSN :
0737-0806
eISSN :
1542-7412
Publisher :
W.B. Saunders
Volume :
94
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
INTA - Instituto Nacional de Tecnología Agropecuaria [AR]
Available on ORBi :
since 17 February 2021

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