[en] Hantaviruses belong to the Bunyaviridae family and are responsible for human diseases called haemorrhagic fever with renal syndrome (HFRS) in Asia and Europe, and hantavirus pulmonary syndrome (HPS) in Americas. Hantaviruses are carried by wild rodents and have been co-evolving with their hosts for millions of years. The genetic diversity among hantaviruses is linked to the specificity of the reservoirs and to their geographical distribution. Host rodents are chronically infected and spread the virus in saliva, urine and faeces. Humans are generally contaminated by inhalation of viral particles from infected material. In Europe, Puumala (PUU) virus is responsible for a mild form of HFRS, called nephropathia epidemica (NE), and Dobrava (DOB) virus causes more severe symptoms that may lead to the death of the patients. Until now, no vaccine against hantaviruses has been available in Europe.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Escutenaire, Sophie; Université de Liège - ULiège > Faculté de médecine vétérinaire > Service d'immunologie-vaccinologie
Brochier, Bernard; Université de Liège - ULiège > Faculté de médecine vétérinaire > Service d'immunologie-vaccinologie
Pastoret, Paul-Pierre ; Université de Liège - ULiège > Faculté de médecine vétérinaire > Service d'immunologie-vaccinologie
Language :
French
Title :
Les hantavirus: Évolution moléculaire et épidémiologie de l'infection
Alternative titles :
[en] Hantaviruses: Molecular evolution and epidemiology of infection
Calisher C.H. (1996) History, classification, and taxonomy of viruses in the family Bunyaviridae. The Bunyaviridae , Elliott RM, ed. New York: Plenum Press; 1-18.
Schmaljohn C.S. (1996) Molecular biology of hantaviruses. The Bunyaviridae , Elliott RM, ed. New York: Plenum Press; 63-90.
Schmaljohn C.S., Hjelle B. (1997) Hantaviruses: A global disease problem. Emerg Infect Dis 3:95-104.
Levis S., Morzunov S.P., Rowe J.E. (1998) Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis 177:529-538.
Young J.C., Mills J.N., Enria D.A., Dolan N.E., Khan A.S., Ksiazek T.G. (1998) New World hantaviruses. Br Med Bull 54:659-673.
Vincent M.J., Quiroz E., Gracia F. (2000) Hantavirus pulmonary syndrome in Panama: Identification of novel hantaviruses and their likely reservoirs. Virology 277:14-19.
Plyusnin A., Morzunov S. (2001) Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol 256:47-75.
Sibold C., Ulrich R., Labuda M. (2001) Dobrava hantavirus causes hemorrhagic fever with renal syndrome in Central Europe and is carried by two different Apodemus mice species. J Med Virol 63:158-167.
Schmaljohn C.S. (1996) Bunyaviridae: The viruses and their replication. Fields virology , Fields BN, Knipe DM, Howley PM, Chanock RM, Helnick JL, Monath TP, Roizman B, Straus SE, eds. Philadelphia: Lippincott-Raven Publishers; 1447-1471.
Gavrilovskaya I.N., Shepley M., Shaw R., Ginsberg M.H., Mackow E.R. (1998) Beta3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci USA 95:7074-7079.
Gavrilovskaya I.N., Brown E.J., Ginsberg M.H., Mackow E.R. (1999) Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol 73:3951-3959.
Alfadhli A., Love Z., Arvidson B., Seeds J., Willey J., Barklis E. (2001) Hantavirus nucleocapsid protein oligomerization. J Virol 75:2019-2023.
Plyusnin A., Vapalahti O., Vaheri A. (1996) Hantaviruses: Genome structure, expression and evolution. J Gen Virol 77:2677-2687.
Morzunov S.P., Rowe J.E., Ksiazek T.G., Peters C.J., St Jeor S.C., Nichol S.T. (1998) Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol 72:5764.
Vapalahti O., Lundkvist A., Fedorov V. (1999) Isolation and characterization of a hantavirus from Lemmus sibiricus: Evidence for host switch during hantavirus evolution. J Virol 73:5586-5592.
Bowen M.D., Gelbmann W., Ksiazek T.G., Nichol S.T., Nowotny N. (1997) Puumala virus and two genetic variants of Tula virus are present in Austrian rodents. J Med Virol 53:174-181.
Lundkvist A., Wiger D., Hörling J. (1998) Isolation and characterization of Puumala hantavirus from Norway: Evidence for a distinct phylogenetic sublineage. J Gen Virol 79:2603-2614.
Heiske A., Anheier B., Pilaski J., Volchkov V.E., Feldmann H. (1999) A new Clethrionomys-derived hantavirus from Germany: Evidence for distinct genetic sublineages of Puumala viruses in Western Europe. Virus Res 61:101-112.
Kariwa H., Yoshimatsu K., Sawabe J. (1999) Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia. Virus Res 59:219-228.
Asikainen K., Hänninen T., Henttonen H. (2000) Molecular evolution of Puumala hantavirus in Fennoscandia: Phylogenetic analysis of strains from two recolonization routes, Karelia and Denmark. J Gen Virol 81:2833-2841.
Escutenaire S., Chalon P., Heyman P. (2001) Genetic characterisation of Puumala hantavirus strains from Belgium: Evidence for a distinct phylogenetic lineage. Virus Res 74:1-15.
Felsenstein J. Phylip (Phylogeny Inference Package), version 3.5c1993.
Johnson A.M., De Souza L.T.M., Ferreira I.B. (1999) Genetic investigation of novel hantaviruses causing fatal HPS in Brazil. J Med Virol 59:527-535.
Henderson W.W., Monroe M.C., St Jeor S.C. (1995) Naturally occurring Sin Nombre virus genetic reassortants. Virology 214:602-610.
Li D., Schmaljohn A.L., Anderson K., Schmaljohn C.S. (1995) Complete nucleotide sequences of the M and S segments of two hantavirus isolates from California: Evidence for reassortment in nature among viruses related to hantavirus pulmonary syndrome. Virology 206:973-983.
Sibold C., Meisel H., Krueger D.H. (1999) Recombination in Tula hantavirus evolution: Analysis of genetic lineages from Slovakia. J Virol 73:667-675.
Monroe M.C., Morzunov S.P., Johnson A.M. (1999) Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America and comparison with other hantaviruses. Emerg Infect Dis 5:75-86.
Domingo E., Holland J., Biebricher C., Eigen M. (1995) Quasi-species: The concept and the word. Molecular basis of virus evolution , Gibbs A, Calisher CH, Garcia-Arenal F, eds. Cambridge: University Press; 81-191.
Peters C.J., Simpson G.L., Levy H. (1999) Spectrum of hantavirus infection: Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Annu Rev Med 50:531-545.
Clement J., McKenna P., Colson P. (1994) Hantavirus epidemic in Europe, 1993. Lancet 343:114.
Le Guenno B., Camprasse M.A., Guilbaut J.C., Lanoux P., Hoen B. (1994) Hantavirus epidemic in Europe, 1993. Lancet 343:114-115.
Heyman P., Vervoort T., Colson P., Chu Y.K., Avsic-Zupanc T., Lundkvist A. (1999) A major outbreak of hantavirus infection in Belgium in 1995 and 1996. Epidemiol Infect 122:447-453.
Nichol S.T., Spiropoulou C.F., Morzunov S. (1993) Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262:914-917.
Duchin J.S., Koster F.T., Peters C.J. (1994) Hantavirus pulmonary syndrome: A clinical description of 17 patients with a newly recognized disease. N Engl J Med 330:949-955.
Padula P.J., Edelstein A., Miguel S.D., Lopez N.M., Rossi C.M., Rabinovich R.D. (1998) Hantavirus pulmonary syndrome outbreak in Argentina: Molecular evidence for person-to-person transmission of Andes virus. Virology 241:323-330.
Cosgriff T.M. (1991) Mechanisms of disease in hantavirus infection: Pathophysiology of hemorrhagic fever with renal syndrome. Rev Infect Dis 13:97-107.
Zaki S.R., Greer P.W., Coffield L.M. (1995) Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol 146:552-579.
Linderholm M., Ahlm C., Settergren B., Waage A., Tärnvik A. (1996) Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome. J Infect Dis 173:38-43.
Mustonen J., Partanen J., Kanerva M. (1996) Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int 49:217-221.
Hjelle B., Jenison S.A., Goade D.E., Green W.B., Feddersen R.M., Scott A.A. (1995) Hantaviruses: Clinical, microbiologic, and epidemiologic aspects. Crit Rev Clin Lab Sci 32:469-508.
McClain D.J., Summers P.L., Harrison S.A., Schmaljohn A.L., Schmaljohn C.S. (2000) Clinical evaluation of a vaccinia-vectored Hantaan virus vaccine. J Med Virol 60:77-85.
Hooper J.W., Kamrud K.I., Elgh F., Custer D., Schmaljohn C.S. (1999) DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects against seoul virus infection. Virology 255:269-278.
Bharadwaj M., Lyons C.R., Hjelle B. (1999) Intramuscular inoculation of Sin Nombre hantavirus cDNAs induces cellular and humoral immune responses in BALB/c mice. Vaccine 17:2836-2843.
Hooper J.W., Li D. (2001) Vaccines against hantaviruses. Curr Top Microbiol Immunol 256:171-191.
Hutchinson K.L., Rollin P.E., Shieh W.J., Zaki S., Greet P.W., Peters C.J. (2000) Transmission of Black Creek Canal virus between cotton rats. J Med Virol 60:70-76.
Kukkonen S.K., Vaheri A., Plyusnin A. (1998) Completion of the Tula hantavirus genome sequence: Properties of the L segment and heterogeneity found in the 3′ termini of S and L genome RNAs. J Gen Virol 79:2615-2622.
Meyer B.J., Schmaljohn C. (2000) Accumulation of terminally deleted RNAs may play a role in Seoul virus persistence. J Virol 74:1321-1331.
Feuer R., Boone J.D., Netski D., Morzunov S.P., St Jeor S.C. (1999) Temporal and spatial analysis of Sin Nombre virus quasispecies in naturally infected rodents. J Virol 73:9544-9554.
Escutenaire S., Chalon P., Verhagen R. (2000) Spatial and temporal dynamics of Puumala hantavirus infection in red bank vole (Clethrionomys glareolus) populations in Belgium. Virus Res 67:91-107.
Hjelle B., Yates T. (2001) Modeling hantavirus maintenance and transmission in rodent communities. Curr Top Microbiol Immunol 256:77-90.